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Cylc2 Gene Detail
Summary
  • Symbol
    Cylc2
  • Name
    cylicin, basic protein of sperm head cytoskeleton 2
  • Synonyms
    4930488P18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922164
    NCBI Gene: 74914
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:51216678-51250622 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 27.27 cM, cytoband B3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1096 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922164
 protein coding gene Chr4:51216653-51250625 (+)
129S1/SvImJ ENSMUSG00200002643
 protein coding gene Chr4:47296217-47330021 (+)
A/J ENSMUSG00195005473
 protein coding gene Chr4:47700408-47734384 (+)
AKR/J ENSMUSG00220002665
 protein coding gene Chr4:47422089-47456009 (+)
BALB/cJ ENSMUSG00180027907
 protein coding gene Chr4:47286967-47320927 (+)
C3H/HeJ ENSMUSG00175021139
 protein coding gene Chr4:47438183-47472158 (+)
C57BL/6NJ ENSMUSG00215020730
 protein coding gene Chr4:47263528-47297472 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026018
 protein coding gene Chr4:44988237-45000212 (+)
CAST/EiJ ENSTCUG00005035852
 protein coding gene Chr4:47547103-47581402 (+)
CBA/J ENSMUSG00210019508
 protein coding gene Chr4:47159565-47193475 (+)
DBA/2J ENSMUSG00185030500
 protein coding gene Chr4:47513613-47547524 (+)
FVB/NJ ENSMUSG00205018481
 protein coding gene Chr4:46806709-46840652 (+)
JF1/MsJ ENSUMUG00000018848
 protein coding gene Chr4:47735787-47770179 (+)
LP/J ENSMUSG00230003038
 protein coding gene Chr4:51098657-51132450 (+)
NOD/ShiLtJ ENSMUSG00190022623
 protein coding gene Chr4:47384424-47418385 (+)
NZO/HlLtJ ENSMUSG00225002422
 protein coding gene Chr4:55682703-55716644 (+)
PWK/PhJ ENSLUMG00010011673
 protein coding gene Chr4:46684239-46718307 (+)
SPRET/EiJ ENSMSPG00010008311
 protein coding gene Chr4:47823846-47836403 (+)
WSB/EiJ ENSIUOG00005004176
 protein coding gene Chr4:47134429-47168380 (+)



Homology
more
  • Human Ortholog
    CYLC2, cylicin 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYLC2, cylicin 2
  • Links
    NCBI Gene ID: 1539
    UniProt: Q14093

  • Chr Location
    9q31.1; chr9:102995311-103018488 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039555 Ensembl Gene Model | MGI Sequence Detail 33945 C57BL/6J ±  kb
transcript ENSMUST00000156384 Ensembl | MGI Sequence Detail 3311 Not Applicable  
polypeptide ENSMUSP00000158665 Ensembl | MGI Sequence Detail 665 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:343074 Schneider S, et al., Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human. Elife. 2023 Nov 28;12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory