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Usp38 Gene Detail
Summary
  • Symbol
    Usp38
  • Name
    ubiquitin specific peptidase 38
  • Synonyms
    4631402N15Rik, 4833420O05Rik, mKIAA1891
  • Feature Type
    protein coding gene
  • IDs
    MGI:1922091
    NCBI Gene: 74841
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:81707362-81741557 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 38.68 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    818 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1922091
 protein coding gene Chr8:81707353-81741631 (-)
129S1/SvImJ ENSMUSG00200022608
 protein coding gene Chr8:76072054-76107445 (-)
A/J ENSMUSG00195016285
 protein coding gene Chr8:76418918-76453190 (-)
AKR/J ENSMUSG00220021424
 protein coding gene Chr8:76505023-76540415 (-)
BALB/cJ ENSMUSG00180016937
 protein coding gene Chr8:76270507-76305903 (-)
C3H/HeJ ENSMUSG00175009890
 protein coding gene Chr8:76348994-76383266 (-)
C57BL/6NJ ENSMUSG00215013315
 protein coding gene Chr8:75985767-76019963 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031258
 protein coding gene Chr8:72471671-72503966 (-)
CAST/EiJ ENSTCUG00005035061
 protein coding gene Chr8:75899388-75934008 (-)
CBA/J ENSMUSG00210019907
 protein coding gene Chr8:76341077-76375352 (-)
DBA/2J ENSMUSG00185035058
 protein coding gene Chr8:82450295-82484565 (-)
FVB/NJ ENSMUSG00205033218
 protein coding gene Chr8:75417047-75451243 (-)
JF1/MsJ ENSUMUG00000026442
 protein coding gene Chr8:84761726-84795951 (-)
LP/J ENSMUSG00230027625
 protein coding gene Chr8:86069077-86104468 (-)
NOD/ShiLtJ ENSMUSG00190022057
 protein coding gene Chr8:76387729-76423120 (-)
NZO/HlLtJ ENSMUSG00225022975
 protein coding gene Chr8:89449165-89483410 (-)
PWK/PhJ ENSLUMG00010025314
 protein coding gene Chr8:76169922-76204115 (-)
SPRET/EiJ ENSMSPG00010021783
 protein coding gene Chr8:77983099-78015287 (-)
WSB/EiJ ENSIUOG00005015341
 protein coding gene Chr8:77149160-77183321 (-)



Homology
more
  • Human Ortholog
    USP38, ubiquitin specific peptidase 38
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP38, ubiquitin specific peptidase 38
  • Synonyms
    HP43.8KD
  • Links
    NCBI Gene ID: 84640
    UniProt: Q8NB14

  • Chr Location
    4q31.21; chr4:143184917-143225212 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to bleomycin-induced inflammation, fibrosis, and lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    46
  • cDNA Data
    110
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038250 Ensembl Gene Model | MGI Sequence Detail 34196 C57BL/6J ±  kb
    transcript ENSMUST00000042724 Ensembl | MGI Sequence Detail 4707 Not Applicable  
    polypeptide ENSMUSP00000039943 Ensembl | MGI Sequence Detail 1042 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017177 ubiquitin carboxyl-terminal hydrolase 38
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR049407 Ubiquitin carboxyl-terminal hydrolase 38-like, N-terminal domain
      IPR050164 Ubiquitin carboxyl-terminal hydrolases
      IPR033840 Ubiquitin-specific peptidase 38
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease USP, catalytic domain
    • GlyGen
      Q8BW70 2 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918043, MGI:2142429, MGI:2142721, MGI:2142798
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 47
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:368745 Qu Z, et al., USP38 stabilizes NOX4 and activates CaMKII to enhance ventricular arrhythmias susceptibility in CKD mice. Free Radic Biol Med. 2025 Jun 6;237:344-356
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory