Senp6 MGI Mouse Gene Detail - MGI:1922075 - SUMO/sentrin specific peptidase 6

Symbol

Senp6
Name

SUMO/sentrin specific peptidase 6
Synonyms

2810017C20Rik, E130319N12Rik, mKIAA0797

Feature Type

protein coding gene
IDs

MGI:1922075
NCBI Gene: 215351
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr9:79974185-80052235 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 43.88 cM
Mapping Data

1 experiment

SNPs within 2kb

1730 from dbSNP Build 142
Strain Annotations

31

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1922075	protein coding gene	Chr9:79973862-80052235 (+)
129S1/SvImJ	ENSMUSGG00200054892	protein coding gene	Chr9:77076045-77101333 (+)
129S1/SvImJ	ENSMUSG00200019064	protein coding gene	Chr9:77101188-77153124 (+)
A/J	ENSMUSG00195009999	protein coding gene	Chr9:76918177-76976644 (+)
A/J	ENSMUSGG00195055414	protein coding gene	Chr9:76893030-76918322 (+)
AKR/J	ENSMUSGG00220054381	protein coding gene	Chr9:76992062-77017347 (+)
AKR/J	ENSMUSG00220014414	protein coding gene	Chr9:77017202-77075673 (+)
BALB/cJ	ENSMUSG00180016669	protein coding gene	Chr9:77028799-77087267 (+)
BALB/cJ	ENSMUSGG00180055465	protein coding gene	Chr9:77003656-77028944 (+)
C3H/HeJ	ENSMUSGG00175054879	protein coding gene	Chr9:77061943-77087227 (+)
C3H/HeJ	ENSMUSG00175010507	protein coding gene	Chr9:77087082-77145549 (+)
C57BL/6NJ	ENSMUSG00215014053	protein coding gene	Chr9:76996051-77047954 (+)
C57BL/6NJ	ENSMUSGG00215055712	protein coding gene	Chr9:76970887-76996196 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032477	protein coding gene	Chr9:76999281-77082712 (+)
CAST/EiJ	ENSTCUG00005008767	protein coding gene	Chr9:76671201-76723196 (+)
CBA/J	ENSMUSGG00210054844	protein coding gene	Chr9:77093311-77118596 (+)
CBA/J	ENSMUSG00210013120	protein coding gene	Chr9:77118451-77176917 (+)
DBA/2J	ENSMUSGG00185057867	protein coding gene	Chr9:77121728-77147016 (+)
DBA/2J	ENSMUSG00185007156	protein coding gene	Chr9:77146871-77205345 (+)
FVB/NJ	ENSMUSG00205026588	protein coding gene	Chr9:77299459-77354595 (+)
FVB/NJ	ENSMUSGG00205054308	protein coding gene	Chr9:77274319-77299604 (+)
JF1/MsJ	ENSUMUG00000020299	protein coding gene	Chr9:77034748-77087221 (+)
LP/J	ENSMUSG00230024049	protein coding gene	Chr9:77250107-77302043 (+)
LP/J	ENSMUSGG00230055311	protein coding gene	Chr9:77224971-77250252 (+)
NOD/ShiLtJ	ENSMUSGG00190054999	protein coding gene	Chr9:77197694-77222985 (+)
NOD/ShiLtJ	ENSMUSG00190028886	protein coding gene	Chr9:77222840-77281303 (+)
NZO/HlLtJ	ENSMUSG00225025068	protein coding gene	Chr9:77444707-77503178 (+)
NZO/HlLtJ	ENSMUSGG00225055482	protein coding gene	Chr9:77419566-77444852 (+)
PWK/PhJ	ENSLUMG00010015769	protein coding gene	Chr9:76978953-77031293 (+)
SPRET/EiJ	ENSMSPG00010003892	protein coding gene	Chr9:78256089-78333276 (+)
WSB/EiJ	ENSIUOG00005024921	protein coding gene	Chr9:76586952-76638970 (+)

Human Ortholog

SENP6, SUMO specific peptidase 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SENP6, SUMO specific peptidase 6
Synonyms

SSP1, SUSP1
Links

HGNC:20944

NCBI Gene ID: 26054

UniProt: Q9GZR1
Chr Location

6q14.1; chr6:75601509-75718281 (+) GRCh38

MGI Vertebrate Homology

Senp6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SENP6
Gene Tree

Senp6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

38
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

26
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Senp6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

100 strains or lines available

Mice homozygous for a gene trap insertion exhibit prenatal lethality.

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All GO Annotations

24
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

2
cDNA Data

164
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase senp6

ZFIN senp6a

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All Sequences

117
RefSeq

28
UniProt

8
CCDS

CCDS40705.1, CCDS81040.1

Ensembl

ENSMUSG00000034252 (Evidence)
NCBI Gene

215351

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034252	Ensembl Gene Model \| MGI Sequence Detail	78051	C57BL/6J	± kb
transcript	ENSMUST00000165607	Ensembl \| MGI Sequence Detail	3495	Not Applicable
polypeptide	ENSMUSP00000126777	Ensembl \| MGI Sequence Detail	1139	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014639 sentrin-specific protease 6

(term hierarchy)
EC

3.4.22.-
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR063139 SENP6/SENP7, PH-like domain

IPR051947 Sentrin-specific protease-like

IPR003653 Ulp1 protease family, C-terminal catalytic domain
GlyGen

Q6P7W0 1 site, 1 O-linked glycan (1 site)

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All nucleic 164

cDNA 164

Microarray probesets 6

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MGI:2442129

Summaries

All 49

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 20
Earliest

J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Senp6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86309	Chr9:79974035-79974046 (+)	-144 bp
Tssr86310	Chr9:79974177-79974218 (+)	13 bp
Tssr86311	Chr9:79974221-79974265 (+)	58 bp
Tssr86312	Chr9:79974269-79974288 (+)	94 bp
Tssr86313	Chr9:79974291-79974329 (+)	125 bp
Tssr86314	Chr9:79974340-79974367 (+)	169 bp
Tssr86315	Chr9:79974369-79974401 (+)	200 bp
Tssr86316	Chr9:79974435-79974447 (+)	256 bp
Tssr86317	Chr9:79974734-79974747 (+)	556 bp
Tssr86318	Chr9:80018659-80018697 (+)	44,493 bp
Tssr86319	Chr9:80020188-80020193 (+)	46,006 bp
Tssr86320	Chr9:80033646-80033666 (+)	59,471 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24