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Dnaaf6rt Gene Detail
Summary
  • Symbol
    Dnaaf6rt
  • Name
    dynein axonemal assembly factor 6, retrotransposed
  • Synonyms
    4930521A18Rik, Dnaaf6, Pih1d3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921958
    NCBI Gene: 74708
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:31261920-31263368 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 11.56 cM, cytoband A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921958
protein coding gene Chr1:31261919-31263369 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015899
protein coding gene Chr1:29464444-29465896 (+)
A/J MGP_AJ_G0015882
protein coding gene Chr1:28748547-28749997 (+)
AKR/J MGP_AKRJ_G0015837
protein coding gene Chr1:29085204-29086656 (+)
BALB/cJ MGP_BALBcJ_G0015836
protein coding gene Chr1:28479289-28480741 (+)
C3H/HeJ MGP_C3HHeJ_G0015670
protein coding gene Chr1:29259598-29261048 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016290
protein coding gene Chr1:30802131-30803581 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014009
protein coding gene Chr1:26250961-26252411 (+)
CAST/EiJ MGP_CASTEiJ_G0015249
protein coding gene Chr1:29154255-29156755 (+)
CBA/J MGP_CBAJ_G0015642
protein coding gene Chr1:31649142-31650580 (+)
DBA/2J MGP_DBA2J_G0015742
protein coding gene Chr1:28193051-28194501 (+)
FVB/NJ MGP_FVBNJ_G0015745
protein coding gene Chr1:27755804-27757254 (+)
LP/J MGP_LPJ_G0015813
protein coding gene Chr1:29733613-29735065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015765
protein coding gene Chr1:33714699-33719736 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016337
protein coding gene Chr1:29045333-29046785 (+)
PWK/PhJ MGP_PWKPhJ_G0015034
protein coding gene Chr1:27873882-27875579 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014813
protein coding gene Chr1:29103882-29105542 (+)
WSB/EiJ MGP_WSBEiJ_G0015313
protein coding gene Chr1:29015584-29017034 (+)



Homology
more
  • Human Ortholog
    DNAAF6, dynein axonemal assembly factor 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNAAF6, dynein axonemal assembly factor 6
  • Synonyms
    CILD36, CXorf41, NYSAR97, PIH1D3, TWISTER
  • Links
    NCBI Gene ID: 139212
    neXtProt AC: NX_Q9NQM4
    UniProt: Q9NQM4

  • Chr Location
    Xq22.3; chrX:107206611-107244247 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human DNAAF6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele develop normally but display male infertility associated with asthenozoospermia and abnormal sperm flagellum morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74708 NCBI Gene Model | MGI Sequence Detail 1449 C57BL/6J ±  kb
    transcript NM_029062 RefSeq | MGI Sequence Detail 1449 C57BL/6  
    polypeptide Q3KNI6 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:6390567, MGI:7519133
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:208266 Dong F, et al., Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm. J Cell Biol. 2014 Jan 20;204(2):203-13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/01/2024
    MGI 6.24
    The Jackson Laboratory