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Lrrc74b Gene Detail
Summary
  • Symbol
    Lrrc74b
  • Name
    leucine rich repeat containing 74B
  • Synonyms
    4930451C15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921935
    NCBI Gene: 74685
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17362329-17379111 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 10.87 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    563 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921935
 protein coding gene Chr16:17362329-17379159 (-)
129S1/SvImJ ENSMUSG00200041925
 protein coding gene Chr16:14358880-14375664 (-)
A/J ENSMUSG00195028284
 protein coding gene Chr16:13916150-13932932 (-)
AKR/J ENSMUSG00220040685
 protein coding gene Chr16:14232427-14249209 (-)
BALB/cJ ENSMUSG00180035832
 protein coding gene Chr16:14157394-14174170 (-)
C3H/HeJ ENSMUSG00175038349
 protein coding gene Chr16:14302410-14319192 (-)
C57BL/6NJ ENSMUSG00215040704
 protein coding gene Chr16:14023538-14040320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020519
 protein coding gene Chr16:14041427-14058895 (-)
CAST/EiJ ENSTCUG00005043012
 protein coding gene Chr16:14216682-14233801 (-)
CBA/J ENSMUSG00210045701
 protein coding gene Chr16:14318716-14335498 (-)
DBA/2J ENSMUSG00185032958
 protein coding gene Chr16:14264872-14281654 (-)
FVB/NJ ENSMUSG00205033648
 protein coding gene Chr16:14272479-14289263 (-)
JF1/MsJ ENSUMUG00000050053
 protein coding gene Chr16:14346928-14363892 (-)
LP/J ENSMUSG00230038955
 protein coding gene Chr16:16842770-16859558 (-)
NOD/ShiLtJ ENSMUSG00190029218
 protein coding gene Chr16:14404786-14421568 (-)
NZO/HlLtJ ENSMUSG00225031458
 protein coding gene Chr16:20088580-20105362 (-)
PWK/PhJ ENSLUMG00010043669
 protein coding gene Chr16:14229175-14246186 (-)
SPRET/EiJ ENSMSPG00010039364
 protein coding gene Chr16:14250952-14266900 (-)
WSB/EiJ ENSIUOG00005039086
 protein coding gene Chr16:14397700-14414840 (-)



Homology
more
  • Human Ortholog
    LRRC74B, leucine rich repeat containing 74B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC74B, leucine rich repeat containing 74B
  • Links
    NCBI Gene ID: 400891
    UniProt: Q6ZQY2

  • Chr Location
    22q11.21; chr22:21045946-21064168 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    13
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022759 Ensembl Gene Model | MGI Sequence Detail 16783 C57BL/6J ±  kb
transcript ENSMUST00000100123 Ensembl | MGI Sequence Detail 2231 Not Applicable  
polypeptide ENSMUSP00000097699 Ensembl | MGI Sequence Detail 391 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Diseases 1
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:359574 Eom TY, et al., Tbx1 haploinsufficiency leads to local skull deformity, paraflocculus and flocculus dysplasia, and motor-learning deficit in 22q11.2 deletion syndrome. Nat Commun. 2024 Dec 5;15(1):10510
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory