Tent5c MGI Mouse Gene Detail - MGI:1921895 - terminal nucleotidyltransferase 5C

Symbol

Tent5c
Name

terminal nucleotidyltransferase 5C
Synonyms

4930431B09Rik, Fam46c

Feature Type

protein coding gene
IDs

MGI:1921895
NCBI Gene: 74645
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr3:100375373-100396508 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 43.71 cM
Mapping Data

2 experiments

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921895	protein coding gene	Chr3:100358944-100396640 (-)
129S1/SvImJ	ENSMUSG00200041198	protein coding gene	Chr3:96979541-97001019 (-)
A/J	ENSMUSG00195042073	protein coding gene	Chr3:97373374-97394850 (-)
AKR/J	ENSMUSG00220038215	protein coding gene	Chr3:95733514-95754990 (-)
BALB/cJ	ENSMUSG00180038692	protein coding gene	Chr3:97313003-97334480 (-)
C3H/HeJ	ENSMUSG00175024525	protein coding gene	Chr3:96859295-96880769 (-)
C57BL/6NJ	ENSMUSG00215022830	protein coding gene	Chr3:97636940-97658429 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025423	protein coding gene	Chr3:94572412-94609874 (-)
CAST/EiJ	ENSTCUG00005018243	protein coding gene	Chr3:97583193-97604641 (-)
CBA/J	ENSMUSG00210050484	protein coding gene	Chr3:97481512-97502987 (-)
DBA/2J	ENSMUSG00185044418	protein coding gene	Chr3:97960355-97981838 (-)
FVB/NJ	ENSMUSG00205027105	protein coding gene	Chr3:96556504-96577994 (-)
JF1/MsJ	ENSUMUG00000046819	protein coding gene	Chr3:96684592-96706100 (-)
LP/J	ENSMUSG00230043137	protein coding gene	Chr3:99908248-99929734 (-)
NOD/ShiLtJ	ENSMUSG00190027622	protein coding gene	Chr3:98159802-98181278 (-)
NZO/HlLtJ	ENSMUSG00225019362	protein coding gene	Chr3:102341005-102362477 (-)
PWK/PhJ	ENSLUMG00010028033	protein coding gene	Chr3:96768686-96790151 (-)
SPRET/EiJ	ENSMSPG00010036770	protein coding gene	Chr3:97028794-97050219 (-)
WSB/EiJ	ENSIUOG00005030784	protein coding gene	Chr3:97500956-97522410 (-)

Human Ortholog

TENT5C, terminal nucleotidyltransferase 5C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TENT5C, terminal nucleotidyltransferase 5C
Synonyms

FAM46C
Links

HGNC:24712

NCBI Gene ID: 54855

UniProt: Q5VWP2
Chr Location

1p12; chr1:117606048-117628389 (+) GRCh38

MGI Vertebrate Homology

Tent5c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TENT5C
Gene Tree

Tent5c

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References

1 with disease annotations

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Phenotype Summary

39 phenotypes from 4 alleles in 3 genetic backgrounds
11 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

10
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tent5c
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit hypochromic microcytic anemia and decreased B cell proliferation. Mice homozygous for a different allele exhibit male infertility associated with oligozoospermia and detachment of the head from flagellum.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

629
Tissues

6
cDNA Data

8
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tent5c

ZFIN tent5c

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All Sequences

41
RefSeq

5
UniProt

1
CCDS

CCDS51017.1

Ensembl

ENSMUSG00000044468 (Evidence)
NCBI Gene

74645

			Length	Strain/Species	Flank
genomic	74645	NCBI Gene Model \| MGI Sequence Detail	21136	C57BL/6J	± kb
transcript	NM_001142952	RefSeq \| MGI Sequence Detail	2054	C57BL/6
polypeptide	Q5SSF7	UniProt \| EBI \| MGI Sequence Detail	391	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030457 terminal nucleotidyltransferase 5C

(term hierarchy)
PDB

7CQZ
EC

2.7.7.19
InterPro Domains

IPR012937 Terminal nucleotidyltransferase

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All nucleic 11

Genomic 2

cDNA 8

Primer pair 1

Microarray probesets 5

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MGI:2139713, MGI:6155754

Summaries

All 59

Developmental Gene Expression 5

Diseases 1

Gene Ontology 12

Phenotypes 24
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:375332 Krawczyk PS, et al., Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines. Nature. 2025 May;641(8064):984-992

TSS for Tent5c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr984	Chr3:100396729-100396734 (-)	-224 bp
Tssr983	Chr3:100396693-100396702 (-)	-190 bp
Tssr34751	Chr3:100396645-100396670 (-)	-150 bp
Tssr34750	Chr3:100396610-100396632 (-)	-113 bp
Tssr34749	Chr3:100396550-100396564 (-)	-49 bp
Tssr34748	Chr3:100396479-100396531 (-)	3 bp
Tssr34747	Chr3:100395257-100395291 (-)	1,234 bp
Tssr34746	Chr3:100390951-100390953 (-)	5,556 bp
Tssr34745	Chr3:100383756-100383761 (-)	12,749 bp
Tssr34744	Chr3:100379914-100379933 (-)	16,584 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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