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Kcnk16 Gene Detail
Summary
  • Symbol
    Kcnk16
  • Name
    potassium channel, subfamily K, member 16
  • Synonyms
    4731413G05Rik, TALK1, TALK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921821
    NCBI Gene: 74571
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20311444-20319267 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.49 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921821
protein coding gene Chr14:20311443-20319337 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021029
protein coding gene Chr14:13015091-13021470 (-)
A/J MGP_AJ_G0020978
protein coding gene Chr14:12716235-12723056 (-)
AKR/J MGP_AKRJ_G0020955
protein coding gene Chr14:13234979-13241370 (-)
BALB/cJ MGP_BALBcJ_G0020981
protein coding gene Chr14:12829165-12835632 (-)
C3H/HeJ MGP_C3HHeJ_G0020765
protein coding gene Chr14:13174019-13180398 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021414
protein coding gene Chr14:13515024-13521413 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018982
protein coding gene Chr14:13028465-13034638 (-)
CAST/EiJ MGP_CASTEiJ_G0020289
protein coding gene Chr14:12925397-12931576 (-)
CBA/J MGP_CBAJ_G0020731
protein coding gene Chr14:14196216-14202611 (-)
DBA/2J MGP_DBA2J_G0020854
protein coding gene Chr14:12547153-12553521 (-)
FVB/NJ MGP_FVBNJ_G0020837
protein coding gene Chr14:12443884-12450251 (-)
LP/J MGP_LPJ_G0020930
protein coding gene Chr14:13229031-13235427 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020863
protein coding gene Chr14:13982396-13988771 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021447
protein coding gene Chr14:13030290-13036570 (-)
PWK/PhJ MGP_PWKPhJ_G0020038
protein coding gene Chr14:12104286-12110797 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019860
protein coding gene Chr14:12800721-12807151 (-)
WSB/EiJ MGP_WSBEiJ_G0020345
protein coding gene Chr14:13011572-13017936 (-)



Homology
more
  • Human Ortholog
    KCNK16, potassium two pore domain channel subfamily K member 16
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK16, potassium two pore domain channel subfamily K member 16
  • Synonyms
    K2p16.1, TALK1, TALK-1
  • Links
    NCBI Gene ID: 83795
    neXtProt AC: NX_Q96T55
    UniProt: Q96T55

  • Chr Location
    6p21.2; chr6:39314570-39322968 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered beta cell electrical excitability, second-phase insulin secretion and glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023387 Ensembl Gene Model | MGI Sequence Detail 7824 C57BL/6J ±  kb
    transcript ENSMUST00000024155 Ensembl | MGI Sequence Detail 916 Not Applicable  
    polypeptide ENSMUSP00000024155 Ensembl | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR013099 Potassium channel domain
      IPR003280 Two pore domain potassium channel
      IPR003092 Two pore domain potassium channel, TASK family
    Molecular
    Reagents
    less
    • All nucleic 6
      Genomic 2
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Gene Ontology 2
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347061 Nakhe AY, et al., The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults. Elife. 2024;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/02/2024
    MGI 6.13
    The Jackson Laboratory