Fam234b MGI Mouse Gene Detail - MGI:1921775 - family with sequence similarity 234, member B

Symbol

Fam234b
Name

family with sequence similarity 234, member B
Synonyms

8430419L09Rik

Feature Type

protein coding gene
IDs

MGI:1921775
NCBI Gene: 74525
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:135173881-135213240 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 66.02 cM, cytoband G1
Mapping Data

3 experiments

SNPs within 2kb

597 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921775	protein coding gene	Chr6:135173881-135221953 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031416	protein coding gene	Chr6:139541108-139592242 (+)
A/J	MGP_AJ_G0031392	protein coding gene	Chr6:134030096-134075420 (+)
AKR/J	MGP_AKRJ_G0031319	protein coding gene	Chr6:138108326-138157756 (+)
BALB/cJ	MGP_BALBcJ_G0031398	protein coding gene	Chr6:133862878-133911132 (+)
C3H/HeJ	MGP_C3HHeJ_G0031120	protein coding gene	Chr6:138147800-138195325 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031858	protein coding gene	Chr6:143333140-143387768 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028990	protein coding gene	Chr6:133184642-133230987 (+)
CAST/EiJ	MGP_CASTEiJ_G0030489	protein coding gene	Chr6:137577536-137637330 (+)
CBA/J	MGP_CBAJ_G0031079	protein coding gene	Chr6:148666318-148719746 (+)
DBA/2J	MGP_DBA2J_G0031237	protein coding gene	Chr6:132881000-132926619 (+)
FVB/NJ	MGP_FVBNJ_G0031187	protein coding gene	Chr6:131802540-131850447 (+)
LP/J	MGP_LPJ_G0031321	protein coding gene	Chr6:139619473-139670106 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031227	protein coding gene	Chr6:152686547-152734695 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031891	protein coding gene	Chr6:137870310-137917933 (+)
PWK/PhJ	MGP_PWKPhJ_G0030214	protein coding gene	Chr6:131384912-131432660 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030038	protein coding gene	Chr6:136030452-136087959 (+)
WSB/EiJ	MGP_WSBEiJ_G0030580	protein coding gene	Chr6:138494660-138545538 (+)

Human Ortholog

FAM234B, family with sequence similarity 234 member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM234B, family with sequence similarity 234 member B
Synonyms

KIAA1467
Links

HGNC:29288

NCBI Gene ID: 57613

neXtProt AC: NX_A2RU67

UniProt: A2RU67
Chr Location

12p13.1; chr12:13044381-13142521 (+) GRCh38

Alliance of Genome Resources

Fam234b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM234B
Gene Tree

Fam234b

less

Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

3
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

29
cDNA Data

89
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam234b

ZFIN fam234b

less

Fam234b interacts with 246 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

less

All Sequences

67
RefSeq

14
UniProt

6
CCDS

CCDS39681.1

Ensembl

ENSMUSG00000030207 (Evidence)
NCBI Gene

74525

			Length	Strain/Species	Flank
genomic	74525	NCBI Gene Model \| MGI Sequence Detail	39360	C57BL/6J	± kb
transcript	NM_028982	RefSeq \| MGI Sequence Detail	4225	C57BL/6
polypeptide	Q8BYI8	UniProt \| EBI \| MGI Sequence Detail	624	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000059680 protein FAM234B

(term hierarchy)
InterPro Domains

IPR045232 Protein FAM234

IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

less

All nucleic 90

cDNA 90

Microarray probesets 6

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Fam234b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59284	Chr6:135173878-135173904 (+)	10 bp
Tssr2037	Chr6:135174979-135174990 (+)	1,104 bp
Tssr59285	Chr6:135175008-135175021 (+)	1,134 bp
Tssr59286	Chr6:135175032-135175060 (+)	1,165 bp
Tssr59287	Chr6:135180438-135180442 (+)	6,559 bp
Tssr59288	Chr6:135191316-135191328 (+)	17,441 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/19/2023 MGI 6.22