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Sohlh2 Gene Detail
Summary
  • Symbol
    Sohlh2
  • Name
    spermatogenesis and oogenesis specific basic helix-loop-helix 2
  • Synonyms
    4933406N12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921684
    NCBI Gene: 74434
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:55089465-55117378 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 26.53 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    823 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921684
 protein coding gene Chr3:55089449-55117378 (+)
129S1/SvImJ ENSMUSG00200022858
 protein coding gene Chr3:51942193-51970120 (+)
A/J ENSMUSG00195030988
 protein coding gene Chr3:51878827-51906758 (+)
AKR/J ENSMUSG00220026431
 protein coding gene Chr3:51948847-51976748 (+)
BALB/cJ ENSMUSG00180024181
 protein coding gene Chr3:51958363-51986056 (+)
C3H/HeJ ENSMUSG00175008267
 protein coding gene Chr3:51800004-51827693 (+)
C57BL/6NJ ENSMUSG00215008037
 protein coding gene Chr3:52236829-52264758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025000
 protein coding gene Chr3:48762177-48789573 (+)
CAST/EiJ ENSTCUG00005009437
 protein coding gene Chr3:51611658-51639511 (+)
CBA/J ENSMUSG00210003565
 protein coding gene Chr3:51921423-51949113 (+)
DBA/2J ENSMUSG00185027762
 protein coding gene Chr3:52127792-52155706 (+)
FVB/NJ ENSMUSG00205008627
 protein coding gene Chr3:51111945-51139698 (+)
JF1/MsJ ENSUMUG00000021806
 protein coding gene Chr3:51570838-51598637 (+)
LP/J ENSMUSG00230004170
 protein coding gene Chr3:54096785-54124714 (+)
NOD/ShiLtJ ENSMUSG00190029772
 protein coding gene Chr3:52296633-52324538 (+)
NZO/HlLtJ ENSMUSG00225016484
 protein coding gene Chr3:56709168-56737098 (+)
PWK/PhJ ENSLUMG00010009381
 protein coding gene Chr3:51681703-51709409 (+)
SPRET/EiJ ENSMSPG00010007294
 protein coding gene Chr3:52450139-52477918 (+)
WSB/EiJ ENSIUOG00005008318
 protein coding gene Chr3:52081249-52109176 (+)



Homology
more
  • Human Ortholog
    CCDC169-SOHLH2, CCDC169-SOHLH2 readthrough
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCDC169-SOHLH2, CCDC169-SOHLH2 readthrough
  • Synonyms
    C13orf38-SOHLH2
  • Links
    NCBI Gene ID: 100526761

  • Chr Location
    13q13.3; chr13:36168217-36297842 (-)  GRCh38
  • Human Ortholog
    SOHLH2, spermatogenesis and oogenesis specific basic helix-loop-helix 2
  • Synonyms
    bHLHe81, SOSF2, SPATA28, TEB1
  • Links
    NCBI Gene ID: 54937
    UniProt: Q9NX45

  • Chr Location
    13q13.3; chr13:36168217-36214588 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to female and male infertility due to defects in early oocyte and spermatogonial differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    144
  • cDNA Data
    11
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74434 NCBI Gene Model | MGI Sequence Detail 27914 C57BL/6J ±  kb
    transcript NM_028937 RefSeq | MGI Sequence Detail 2351 C57BL/6  
    polypeptide Q9D489 UniProt | EBI | MGI Sequence Detail 467 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000015403 spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
      (term hierarchy)
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR039583 Transcription factor-like 5/SOLH1/2
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 11
      Primer pair 10
      Other 1
      Antibodies 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139689
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:338939 Graham-Paquin AL, et al., ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development. Nucleic Acids Res. 2023 Aug 11;51(14):7314-7329
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory