Gle1 MGI Mouse Gene Detail - MGI:1921662 - GLE1 RNA export mediator

Symbol

Gle1
Name

GLE1 RNA export mediator
Synonyms

4933405K21Rik

Feature Type

protein coding gene
IDs

MGI:1921662
NCBI Gene: 74412
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:29825421-29849444 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 20.88 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

696 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921662	protein coding gene	Chr2:29825421-29850383 (+)
129S1/SvImJ	ENSMUSG00200048062	protein coding gene	Chr2:26795841-26820804 (+)
A/J	ENSMUSG00195038506	protein coding gene	Chr2:26889251-26914201 (+)
AKR/J	ENSMUSG00220050553	protein coding gene	Chr2:27007802-27032749 (+)
BALB/cJ	ENSMUSG00180052763	protein coding gene	Chr2:26908542-26933493 (+)
C3H/HeJ	ENSMUSG00175052944	protein coding gene	Chr2:26877869-26902815 (+)
C57BL/6NJ	ENSMUSG00215048679	protein coding gene	Chr2:26943506-26968452 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023375	protein coding gene	Chr2:25799883-25826253 (+)
CAST/EiJ	ENSTCUG00005051693	protein coding gene	Chr2:26614826-26639791 (+)
CBA/J	ENSMUSG00210016641	protein coding gene	Chr2:26911022-26935971 (+)
DBA/2J	ENSMUSG00185048873	protein coding gene	Chr2:26803324-26828272 (+)
FVB/NJ	ENSMUSG00205047420	protein coding gene	Chr2:26655370-26680320 (+)
JF1/MsJ	ENSUMUG00000023990	protein coding gene	Chr2:26698984-26724017 (+)
LP/J	ENSMUSG00230039162	protein coding gene	Chr2:28731586-28756548 (+)
NOD/ShiLtJ	ENSMUSG00190044285	protein coding gene	Chr2:26910151-26935011 (+)
NZO/HlLtJ	ENSMUSG00225007748	protein coding gene	Chr2:36481212-36506184 (+)
PWK/PhJ	ENSLUMG00010049509	protein coding gene	Chr2:26775912-26800843 (+)
SPRET/EiJ	ENSMSPG00010043031	protein coding gene	Chr2:27498624-27523077 (+)
WSB/EiJ	ENSIUOG00005052147	protein coding gene	Chr2:26761398-26786345 (+)

Human Ortholog

GLE1, GLE1 RNA export mediator

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GLE1, GLE1 RNA export mediator
Synonyms

CAAHC, CAAHD, GLE1L, hGLE1, LCCS, LCCS1
Links

HGNC:4315

NCBI Gene ID: 2733

UniProt: Q53GS7
Chr Location

9q34.11; chr9:128504655-128543874 (+) GRCh38

MGI Vertebrate Homology

Gle1 stringent orthology
1 human;1 mouse;3 rat;1 zebrafish
HCOP

vertebrate homology predictions: GLE1
Gene Tree

Gle1

Diseases

1 with human GLE1 associations

				Human Disease	Mouse Models
				lethal congenital contracture syndrome 1 IDs lethal congenital contracture syndrome 1 DOID:0060559 MESH:C537194 OMIM:253310 ORDO:1486 UMLS_CUI:C1854664

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

5
Gene trapped

10
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

619
Tissues

22
cDNA Data

15
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gle1

ZFIN gle1

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All Sequences

57
RefSeq

4
UniProt

1
CCDS

CCDS15862.1

Ensembl

ENSMUSG00000019715 (Evidence)
NCBI Gene

74412

			Length	Strain/Species	Flank
genomic	74412	NCBI Gene Model \| MGI Sequence Detail	24024	C57BL/6J	± kb
transcript	NM_028923	RefSeq \| MGI Sequence Detail	3138	C57BL/6
polypeptide	Q8R322	UniProt \| EBI \| MGI Sequence Detail	699	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008024 mRNA export factor GLE1

(term hierarchy)
InterPro Domains

IPR038506 GLE1-like superfamily

IPR012476 mRNA export factor GLE1-like

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 6

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MGI:2138794

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:374738 Zarybnicky T, et al., In vivo modeling of lethal congenital contracture syndrome 1 suggests pathomechanisms in cellular stress responses. FEBS J. 2025;

TSS for Gle1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17052	Chr2:29825425-29825511 (+)	47 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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