Odad4 MGI Mouse Gene Detail - MGI:1921657 - outer dynein arm complex subunit 4

Symbol

Odad4
Name

outer dynein arm complex subunit 4
Synonyms

4933404O19Rik, Ttc25

Feature Type

protein coding gene
IDs

MGI:1921657
NCBI Gene: 74407
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:100436434-100463392 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.47 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

134 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921657	protein coding gene	Chr11:100436433-100463394 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019159	protein coding gene	Chr11:103306729-103333507 (+)
A/J	MGP_AJ_G0019127	protein coding gene	Chr11:98995646-99023400 (+)
AKR/J	MGP_AKRJ_G0019096	protein coding gene	Chr11:102055212-102083969 (+)
BALB/cJ	MGP_BALBcJ_G0019101	protein coding gene	Chr11:99475234-99505690 (+)
C3H/HeJ	MGP_C3HHeJ_G0018910	protein coding gene	Chr11:102241467-102270359 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019550	protein coding gene	Chr11:106520026-106551139 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017176	protein coding gene	Chr11:96415172-96442608 (+)
CAST/EiJ	MGP_CASTEiJ_G0018464	protein coding gene	Chr11:103220137-103247021 (+)
CBA/J	MGP_CBAJ_G0018879	protein coding gene	Chr11:110949419-110982776 (+)
DBA/2J	MGP_DBA2J_G0018991	protein coding gene	Chr11:98534048-98560198 (+)
FVB/NJ	MGP_FVBNJ_G0018981	protein coding gene	Chr11:98068355-98095811 (+)
LP/J	MGP_LPJ_G0019060	protein coding gene	Chr11:103861220-103897429 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019012	protein coding gene	Chr11:110553539-110585703 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019588	protein coding gene	Chr11:102388888-102491772 (+)
PWK/PhJ	MGP_PWKPhJ_G0018227	protein coding gene	Chr11:99573280-99600173 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018019	protein coding gene	Chr11:102123884-102152949 (+)
WSB/EiJ	MGP_WSBEiJ_G0018513	protein coding gene	Chr11:102373260-102401433 (+)

Human Ortholog

ODAD4, outer dynein arm docking complex subunit 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ODAD4, outer dynein arm docking complex subunit 4
Synonyms

TTC25
Links

HGNC:25280

NCBI Gene ID: 83538

neXtProt AC: NX_Q96NG3

UniProt: Q96NG3
Chr Location

17q21.2; chr17:41930617-41966503 (+) GRCh38

Alliance of Genome Resources

Odad4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ODAD4
Gene Tree

Odad4

Diseases

1 with Odad4 mouse models; 1 with human ODAD4 associations

Human Disease

Mouse Models

primary ciliary dyskinesia 35

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

2
Gene trapped

23
Targeted

5
Genomic Mutations

3 involving Odad4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display partial preweaning lethality, impaired ciliary motility, and a variety of left-right body symmetry defects.

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All GO Annotations

21
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

22
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase odad4

ZFIN odad4

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Odad4 interacts with 141 markers (Mir16-2, Mir22, Mir26a-2, ...) View All

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All Sequences

48
RefSeq

7
UniProt

4
CCDS

CCDS36331.1, CCDS88255.1

Ensembl

ENSMUSG00000006784 (Evidence)
NCBI Gene

74407

			Length	Strain/Species	Flank
genomic	74407	NCBI Gene Model \| MGI Sequence Detail	26959	C57BL/6J	± kb
transcript	NM_028918	RefSeq \| MGI Sequence Detail	2842	C57BL/6
polypeptide	Q9D4B2	UniProt \| EBI \| MGI Sequence Detail	624	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029833 outer dynein arm-docking complex subunit 4

(term hierarchy)
InterPro Domains

IPR040111 Outer dynein arm-docking complex subunit 4

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

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All nucleic 23

cDNA 22

Other 1

Microarray probesets 4

Summaries

All 40

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 14
Earliest

J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
Latest

J:301033 Ide T, et al., CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components. PLoS Genet. 2020 Dec;16(12):e1009232

TSS for Odad4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104940	Chr11:100436498-100436504 (+)	67 bp
Tssr104941	Chr11:100436509-100436562 (+)	102 bp
Tssr104942	Chr11:100444165-100444169 (+)	7,733 bp
Tssr104943	Chr11:100444825-100444844 (+)	8,401 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/19/2023 MGI 6.22