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Duxf3 Gene Detail
Summary
  • Symbol
    Duxf3
  • Name
    double homeobox family member 3
  • Synonyms
    4933403O03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921649
    NCBI Gene: 74399
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr10:58066473-58068497 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 29.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921649
 protein coding gene Chr10:58064887-58070140 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017243
 protein coding gene Chr10:57310926-57322220 (-)
A/J MGP_AJ_G0017220
 protein coding gene Chr10:55662484-55668258 (-)
AKR/J MGP_AKRJ_G0017179
 protein coding gene Chr10:57103006-57112122 (-)
BALB/cJ MGP_BALBcJ_G0017181
 protein coding gene Chr10:55751980-55757664 (-)
C3H/HeJ MGP_C3HHeJ_G0017003
 protein coding gene Chr10:57021587-57033785 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0016975
 protein coding gene Chr10:61530485-61545629 (-)
DBA/2J MGP_DBA2J_G0017081
 protein coding gene Chr10:55004580-55007404 (-)
FVB/NJ MGP_FVBNJ_G0017075
 protein coding gene Chr10:54220021-54221475 (-)
LP/J MGP_LPJ_G0017155
 protein coding gene Chr10:57701619-57719022 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0016359
 protein coding gene Chr10:54771720-54774394 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    7 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Duxf3
  • Find Mice (IMSR)
    7 strains or lines available
Mice homozygous for null alleles in each genes of the Dux cluster exhibit delayed zygotic gene activation and decreased development potential of embryos.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
Sequences &
Gene Models
less
  • All Sequences
    20
  • RefSeq
    2
  • UniProt
    2
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075046 Ensembl Gene Model | MGI Sequence Detail 2025 C57BL/6J ±  kb
transcript ENSMUST00000176875 Ensembl | MGI Sequence Detail 2025 Not Applicable  
polypeptide ENSMUSP00000145004 Ensembl | MGI Sequence Detail 674 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001356 Homeobox domain
    IPR009057 Homeobox-like domain superfamily
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 18
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:328721 Guo M, et al., Precise temporal regulation of Dux is important for embryo development. Cell Res. 2019 Nov;29(11):956-959
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory