Rmi1 MGI Mouse Gene Detail - MGI:1921636 - RecQ mediated genome instability 1

Symbol

Rmi1
Name

RecQ mediated genome instability 1
Synonyms

4932432N11Rik

Feature Type

protein coding gene
IDs

MGI:1921636
NCBI Gene: 74386
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:58550062-58558962 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 31.05 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

39 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921636	protein coding gene	Chr13:58550062-58558963 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020634	protein coding gene	Chr13:58042763-58051324 (+)
A/J	MGP_AJ_G0020588	protein coding gene	Chr13:55889670-55898228 (+)
AKR/J	MGP_AKRJ_G0020566	protein coding gene	Chr13:57551940-57560492 (+)
BALB/cJ	MGP_BALBcJ_G0020584	protein coding gene	Chr13:56148248-56156762 (+)
C3H/HeJ	MGP_C3HHeJ_G0020383	protein coding gene	Chr13:57359367-57368090 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021018	protein coding gene	Chr13:59825330-59833883 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018600	protein coding gene	Chr13:53781318-53789575 (+)
CAST/EiJ	MGP_CASTEiJ_G0019897	protein coding gene	Chr13:57492382-57503729 (+)
CBA/J	MGP_CBAJ_G0020343	protein coding gene	Chr13:62074480-62083037 (+)
DBA/2J	MGP_DBA2J_G0020466	protein coding gene	Chr13:55439524-55448075 (+)
FVB/NJ	MGP_FVBNJ_G0020445	protein coding gene	Chr13:54916512-54925156 (+)
LP/J	MGP_LPJ_G0020542	protein coding gene	Chr13:58314543-58323075 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020474	protein coding gene	Chr13:61433981-61442533 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021061	protein coding gene	Chr13:57155914-57168463 (+)
PWK/PhJ	MGP_PWKPhJ_G0019653	protein coding gene	Chr13:55447393-55456194 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019480	protein coding gene	Chr13:56065286-56073917 (+)
WSB/EiJ	MGP_WSBEiJ_G0019959	protein coding gene	Chr13:57589100-57599502 (+)

Human Ortholog

RMI1, RecQ mediated genome instability 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RMI1, RecQ mediated genome instability 1
Synonyms

BLAP75, C9orf76, FAAP75
Links

HGNC:25764

NCBI Gene ID: 80010

neXtProt AC: NX_Q9H9A7

UniProt: Q9H9A7
Chr Location

9q21.32; chr9:83980359-84004074 (+) GRCh38

MGI Vertebrate Homology

Rmi1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RMI1
Gene Tree

Rmi1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
8 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

12
Genomic Mutations

1 involving Rmi1
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele exhibit decreased weight and increased resistance to diet-induced obesity.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

1
cDNA Data

48
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rmi1

ZFIN rmi1

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All Sequences

50
RefSeq

9
UniProt

1
CCDS

CCDS26571.1

Ensembl

ENSMUSG00000035367 (Evidence)
NCBI Gene

74386

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035367	Ensembl Gene Model \| MGI Sequence Detail	8901	C57BL/6J	± kb
transcript	ENSMUST00000224479	Ensembl \| MGI Sequence Detail	4212	Not Applicable
polypeptide	ENSMUSP00000153050	Ensembl \| MGI Sequence Detail	616	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014036 RecQ-mediated genome instability protein 1

(term hierarchy)
InterPro Domains

IPR032199 RecQ-mediated genome instability protein 1, C-terminal OB-fold domain

IPR044881 RecQ-mediated genome instability protein 1, N-terminal helical domain superfamily

IPR013894 RecQ mediated genome instability protein 1, OB-fold domain

IPR042470 RecQ mediated genome instability protein, N-terminal OB-fold domain superfamily

IPR049363 RMI1, N-terminal domain

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All nucleic 49

cDNA 48

Primer pair 1

Microarray probesets 6

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MGI:2145511

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 10
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:319969 Xue X, et al., Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIalpha-RMI1-RMI2 protein complex. J Biol Chem. 2013 May 17;288(20):14221-14227

TSS for Rmi1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120077	Chr13:58550047-58550075 (+)	-1 bp
Tssr120078	Chr13:58550360-58550392 (+)	314 bp
Tssr120079	Chr13:58550499-58550519 (+)	447 bp
Tssr120080	Chr13:58550522-58550541 (+)	470 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23