4931414P19Rik MGI Mouse Gene Detail - MGI:1921609

Symbol

4931414P19Rik
Name

RIKEN cDNA 4931414P19 gene

Feature Type

protein coding gene
IDs

MGI:1921609
NCBI Gene: 74359
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:54821120-54843450 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 27.85 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

605 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921609	protein coding gene	Chr14:54821119-54843450 (-)
129S1/SvImJ	ENSMUSG00200040459	protein coding gene	Chr14:43402162-43424547 (-)
A/J	ENSMUSG00195028621	protein coding gene	Chr14:43626458-43648847 (-)
AKR/J	ENSMUSG00220025516	protein coding gene	Chr14:42954428-42976812 (-)
BALB/cJ	ENSMUSG00180046329	protein coding gene	Chr14:43250231-43272614 (-)
C3H/HeJ	ENSMUSG00175047648	protein coding gene	Chr14:44932634-44955014 (-)
C57BL/6NJ	ENSMUSG00215046626	protein coding gene	Chr14:43144071-43166404 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019261	protein coding gene	Chr14:46010112-46033084 (-)
CAST/EiJ	ENSTCUG00005047157	protein coding gene	Chr14:44930008-44952103 (-)
CBA/J	ENSMUSG00210043430	protein coding gene	Chr14:43613178-43635556 (-)
DBA/2J	ENSMUSG00185050306	protein coding gene	Chr14:48660217-48682335 (-)
FVB/NJ	ENSMUSG00205031189	protein coding gene	Chr14:43002582-43024951 (-)
JF1/MsJ	ENSUMUG00000020731	protein coding gene	Chr14:59907486-59929492 (-)
LP/J	ENSMUSG00230052611	protein coding gene	Chr14:60767893-60790514 (-)
NOD/ShiLtJ	ENSMUSG00190035420	protein coding gene	Chr14:43363466-43385837 (-)
NZO/HlLtJ	ENSMUSG00225048848	protein coding gene	Chr14:51066021-51088645 (-)
PWK/PhJ	ENSLUMG00010046302	protein coding gene	Chr14:42836091-42858470 (-)
SPRET/EiJ	ENSMSPG00010038667	protein coding gene	Chr14:46234003-46245927 (-)
WSB/EiJ	ENSIUOG00005034287	protein coding gene	Chr14:42828268-42850321 (-)

Human Ortholog

C14orf93, chromosome 14 open reading frame 93

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C14orf93, chromosome 14 open reading frame 93
Synonyms

RTFC
Links

HGNC:20162

NCBI Gene ID: 60686

UniProt: Q9H972
Chr Location

14q11.2; chr14:22985894-23010529 (-) GRCh38

MGI Vertebrate Homology

4931414P19Rik stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: C14orf93
Gene Tree

4931414P19Rik

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

17
Targeted

1
Genomic Mutations

1 involving 4931414P19Rik
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit mild hypothyrodism in female, but not male, mice.

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

18

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

46
RefSeq

12
UniProt

3
CCDS

CCDS27094.1

Ensembl

ENSMUSG00000022179 (Evidence)
NCBI Gene

74359

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022179	Ensembl Gene Model \| MGI Sequence Detail	22331	C57BL/6J	± kb
transcript	ENSMUST00000022786	Ensembl \| MGI Sequence Detail	2670	Not Applicable
polypeptide	ENSMUSP00000022786	Ensembl \| MGI Sequence Detail	541	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000060094 uncharacterized protein C14orf93

(term hierarchy)
InterPro Domains

IPR028101 Protein of unknown function DUF4616

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All nucleic 18

cDNA 18

Microarray probesets 3

Summaries

All 30

Gene Ontology 2

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:341275 Mestres I, et al., 4931414P19Rik, a microglia chemoattractant secreted by neural progenitors, modulates neuronal migration during corticogenesis. Development. 2023 May 1;150(9)

TSS for 4931414P19Rik:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128609	Chr14:54843366-54843392 (-)	71 bp
Tssr128608	Chr14:54840833-54840857 (-)	2,605 bp
Tssr128607	Chr14:54840812-54840828 (-)	2,630 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24