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Xrcc3 Gene Detail
Summary
  • Symbol
    Xrcc3
  • Name
    X-ray repair complementing defective repair in Chinese hamster cells 3
  • Synonyms
    4432412E01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921585
    NCBI Gene: 74335
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111769626-111780307 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921585
 protein coding gene Chr12:111769626-111780326 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020142
 protein coding gene Chr12:114222009-114234191 (-)
A/J MGP_AJ_G0020098
 protein coding gene Chr12:109831566-109842097 (-)
AKR/J MGP_AKRJ_G0020073
 protein coding gene Chr12:112979840-112990371 (-)
BALB/cJ MGP_BALBcJ_G0020083
 protein coding gene Chr12:110250850-110261575 (-)
C3H/HeJ MGP_C3HHeJ_G0019885
 protein coding gene Chr12:113479248-113489779 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020528
 protein coding gene Chr12:117770038-117782433 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018141
 protein coding gene Chr12:106264368-106274860 (-)
CAST/EiJ MGP_CASTEiJ_G0019426
 protein coding gene Chr12:108331055-108341699 (-)
CBA/J MGP_CBAJ_G0019852
 protein coding gene Chr12:122266341-122279911 (-)
DBA/2J MGP_DBA2J_G0019969
 protein coding gene Chr12:109306952-109317483 (-)
FVB/NJ MGP_FVBNJ_G0019954
 protein coding gene Chr12:108115527-108126055 (-)
LP/J MGP_LPJ_G0020044
 protein coding gene Chr12:114050770-114062649 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019992
 protein coding gene Chr12:125372565-125384435 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020557
 protein coding gene Chr12:112501185-112512742 (-)
PWK/PhJ MGP_PWKPhJ_G0019187
 protein coding gene Chr12:103953976-103965443 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018990
 protein coding gene Chr12:106664669-106675229 (-)
WSB/EiJ MGP_WSBEiJ_G0019485
 protein coding gene Chr12:113408408-113418979 (-)



Homology
more
  • Human Ortholog
    XRCC3, X-ray repair cross complementing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XRCC3, X-ray repair cross complementing 3
  • Synonyms
    CMM6
  • Links
    NCBI Gene ID: 7517
    neXtProt AC: NX_O43542
    UniProt: O43542

  • Chr Location
    14q32.33; chr14:103697609-103715504 (-)  GRCh38
Human Diseases
more
  • Diseases
    11 with human XRCC3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit growth arrest at the 6-8 somite stage prior to axial rotation and embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    19
  • cDNA Data
    22
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021287 Ensembl Gene Model | MGI Sequence Detail 10682 C57BL/6J ±  kb
    transcript ENSMUST00000021715 Ensembl | MGI Sequence Detail 2422 Not Applicable  
    polypeptide ENSMUSP00000021715 Ensembl | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017506 DNA repair protein XRCC3
      (term hierarchy)
    • InterPro Domains
      IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
      IPR016467 DNA recombination and repair protein, RecA-like
      IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
      IPR047348 DNA repair protein XRCC3-like, C-terminal
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144770, MGI:2145034
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:320381 Prakash R, et al., XRCC3 loss leads to midgestational embryonic lethality in mice. DNA Repair (Amst). 2021 Dec;108:103227
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory