Inava MGI Mouse Gene Detail - MGI:1921579 - innate immunity activator

Symbol

Inava
Name

innate immunity activator
Synonyms

1700034M08Rik, 5730559C18Rik

Feature Type

protein coding gene
IDs

MGI:1921579
NCBI Gene: 67313
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:136141269-136162002 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.61 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

183 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921579	protein coding gene	Chr1:136141260-136162045 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016538	protein coding gene	Chr1:140029064-140049828 (-)
A/J	MGP_AJ_G0016521	protein coding gene	Chr1:134721532-134742253 (-)
AKR/J	MGP_AKRJ_G0016486	protein coding gene	Chr1:138726446-138747177 (-)
BALB/cJ	MGP_BALBcJ_G0016481	protein coding gene	Chr1:135050856-135072156 (-)
C3H/HeJ	MGP_C3HHeJ_G0016307	protein coding gene	Chr1:138822118-138842757 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016942	protein coding gene	Chr1:145048769-145069487 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014653	protein coding gene	Chr1:127829169-127849845 (-)
CAST/EiJ	MGP_CASTEiJ_G0015887	protein coding gene	Chr1:137922657-137943372 (-)
CBA/J	MGP_CBAJ_G0016280	protein coding gene	Chr1:150071653-150092364 (-)
DBA/2J	MGP_DBA2J_G0016386	protein coding gene	Chr1:133715009-133735827 (-)
FVB/NJ	MGP_FVBNJ_G0016385	protein coding gene	Chr1:132363415-132384501 (-)
LP/J	MGP_LPJ_G0016457	protein coding gene	Chr1:141248806-141269563 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016410	protein coding gene	Chr1:155714632-155735384 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016978	protein coding gene	Chr1:138491267-138511850 (-)
PWK/PhJ	MGP_PWKPhJ_G0015673	protein coding gene	Chr1:132764463-132785488 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015460	protein coding gene	Chr1:137483553-137504122 (-)
WSB/EiJ	MGP_WSBEiJ_G0015950	protein coding gene	Chr1:138535288-138556053 (-)

Human Ortholog

INAVA, innate immunity activator

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INAVA, innate immunity activator
Synonyms

C1orf106
Links

HGNC:25599

NCBI Gene ID: 55765

neXtProt AC: NX_Q3KP66

UniProt: Q3KP66
Chr Location

1q32.1; chr1:200891048-200915742 (+) GRCh38

Alliance of Genome Resources

Inava stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: INAVA
Gene Tree

Inava

Diseases

1 with human INAVA associations

				Human Disease	Mouse Models
				inflammatory bowel disease 29 IDs inflammatory bowel disease 29 DOID:0112155 OMIM:618077

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Gene trapped

10
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Inava
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele have defects in the intestinal epithelial cell barrier and exhibit increased susceptibility to DSS-induced colitis and Citrobacter rodentium infection.

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All GO Annotations

25
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

775
Tissues

10
cDNA Data

33
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Inava interacts with 101 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

59
RefSeq

12
UniProt

6
CCDS

CCDS15325.2

Ensembl

ENSMUSG00000041605 (Evidence)
NCBI Gene

67313

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041605	Ensembl Gene Model \| MGI Sequence Detail	20734	C57BL/6J	± kb
transcript	ENSMUST00000120339	Ensembl \| MGI Sequence Detail	2988	Not Applicable
polypeptide	ENSMUSP00000113785	Ensembl \| MGI Sequence Detail	663	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000059795 innate immunity activator protein

(term hierarchy)
InterPro Domains

IPR043447 CCDC120/INAVA

IPR021774 Cytohesin Ubiquitin Protein Inducing Domain

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All nucleic 34

Genomic 1

cDNA 33

Microarray probesets 4

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MGI:1914563

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Inava:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13927	Chr1:136161851-136161872 (-)	140 bp
Tssr13926	Chr1:136161791-136161818 (-)	197 bp
Tssr13925	Chr1:136161776-136161789 (-)	219 bp
Tssr13924	Chr1:136158120-136158132 (-)	3,876 bp
Tssr13923	Chr1:136158072-136158093 (-)	3,919 bp
Tssr13922	Chr1:136158045-136158070 (-)	3,944 bp
Tssr229	Chr1:136148122-136148130 (-)	13,876 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/19/2023 MGI 6.22