Inava MGI Mouse Gene Detail - MGI:1921579 - innate immunity activator

Symbol

Inava
Name

innate immunity activator
Synonyms

1700034M08Rik, 5730559C18Rik

Feature Type

protein coding gene
IDs

MGI:1921579
NCBI Gene: 67313
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:136141269-136162002 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.61 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

627 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921579	protein coding gene	Chr1:136141259-136162045 (-)
129S1/SvImJ	ENSMUSG00200007186	protein coding gene	Chr1:133765607-133786359 (-)
A/J	ENSMUSG00195015766	protein coding gene	Chr1:132828835-132849566 (-)
AKR/J	ENSMUSG00220002717	protein coding gene	Chr1:132719693-132740424 (-)
BALB/cJ	ENSMUSG00180011171	protein coding gene	Chr1:133369388-133390118 (-)
C3H/HeJ	ENSMUSG00175006362	protein coding gene	Chr1:133072876-133093598 (-)
C57BL/6NJ	ENSMUSG00215013997	protein coding gene	Chr1:133071228-133091961 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014653	protein coding gene	Chr1:127829169-127849845 (-)
CAST/EiJ	ENSTCUG00005037913	protein coding gene	Chr1:132005499-132026237 (-)
CBA/J	ENSMUSG00210013996	protein coding gene	Chr1:133003189-133023915 (-)
DBA/2J	ENSMUSG00185029896	protein coding gene	Chr1:137380453-137401164 (-)
FVB/NJ	ENSMUSG00205002195	protein coding gene	Chr1:132338909-132359639 (-)
JF1/MsJ	ENSUMUG00000046077	protein coding gene	Chr1:136507777-136528572 (-)
LP/J	ENSMUSG00230033327	protein coding gene	Chr1:136903981-136924714 (-)
NOD/ShiLtJ	ENSMUSG00190002232	protein coding gene	Chr1:133017198-133037923 (-)
NZO/HlLtJ	ENSMUSG00225019916	protein coding gene	Chr1:140670959-140691689 (-)
PWK/PhJ	ENSLUMG00010001768	protein coding gene	Chr1:132131563-132152316 (-)
SPRET/EiJ	ENSMSPG00010011900	protein coding gene	Chr1:134933149-134953148 (-)
WSB/EiJ	ENSIUOG00005027724	protein coding gene	Chr1:132786925-132807673 (-)

Human Ortholog

INAVA, innate immunity activator

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INAVA, innate immunity activator
Synonyms

C1orf106
Links

HGNC:25599

NCBI Gene ID: 55765

UniProt: Q3KP66
Chr Location

1q32.1; chr1:200891003-200915742 (+) GRCh38

MGI Vertebrate Homology

Inava stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: INAVA
Gene Tree

Inava

Diseases

1 with human INAVA associations

				Human Disease	Mouse Models
				inflammatory bowel disease 29 IDs inflammatory bowel disease 29 DOID:0112155 OMIM:618077

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Gene trapped

10
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Inava
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele have defects in the intestinal epithelial cell barrier and exhibit increased susceptibility to DSS-induced colitis and Citrobacter rodentium infection.

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All GO Annotations

59
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

666
Tissues

10
cDNA Data

33
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

60
RefSeq

12
UniProt

6
CCDS

CCDS15325.2

Ensembl

ENSMUSG00000041605 (Evidence)
NCBI Gene

67313

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041605	Ensembl Gene Model \| MGI Sequence Detail	20734	C57BL/6J	± kb
transcript	ENSMUST00000120339	Ensembl \| MGI Sequence Detail	2988	Not Applicable
polypeptide	ENSMUSP00000113785	Ensembl \| MGI Sequence Detail	663	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000059795 innate immunity activator protein

(term hierarchy)
InterPro Domains

IPR043447 CCDC120/INAVA

IPR021774 Cytohesin Ubiquitin Protein Inducing Domain
GlyGen

Q7TN12 2 sites

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All nucleic 34

Genomic 1

cDNA 33

Microarray probesets 4

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MGI:1914563, MGI:6156587

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Inava:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13927	Chr1:136161851-136161872 (-)	140 bp
Tssr13926	Chr1:136161791-136161818 (-)	197 bp
Tssr13925	Chr1:136161776-136161789 (-)	219 bp
Tssr13924	Chr1:136158120-136158132 (-)	3,876 bp
Tssr13923	Chr1:136158072-136158093 (-)	3,919 bp
Tssr13922	Chr1:136158045-136158070 (-)	3,944 bp
Tssr229	Chr1:136148122-136148130 (-)	13,876 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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