Tspan17 MGI Mouse Gene Detail - MGI:1921507

Symbol

Tspan17
Name

tetraspanin 17
Synonyms

2210021G21Rik, Fbxo23, Tm4sf17

Feature Type

protein coding gene
IDs

MGI:1921507
NCBI Gene: 74257
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:54937190-54944589 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.41 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

338 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921507	protein coding gene	Chr13:54936915-54944589 (+)
129S1/SvImJ	ENSMUSG00200015091	protein coding gene	Chr13:51809622-51817023 (+)
A/J	ENSMUSG00195038620	protein coding gene	Chr13:51276430-51283830 (+)
AKR/J	ENSMUSG00220034760	protein coding gene	Chr13:50821039-50828426 (+)
BALB/cJ	ENSMUSG00180015044	protein coding gene	Chr13:51527700-51535102 (+)
C3H/HeJ	ENSMUSG00175040215	protein coding gene	Chr13:51314175-51321577 (+)
C57BL/6NJ	ENSMUSG00215038315	protein coding gene	Chr13:51338670-51346069 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018547	protein coding gene	Chr13:50206846-50214244 (+)
CAST/EiJ	ENSTCUG00005035004	protein coding gene	Chr13:51732973-51740412 (+)
CBA/J	ENSMUSG00210036748	protein coding gene	Chr13:51518990-51526390 (+)
DBA/2J	ENSMUSG00185016070	protein coding gene	Chr13:52360936-52368335 (+)
FVB/NJ	ENSMUSG00205022969	protein coding gene	Chr13:51167772-51175173 (+)
JF1/MsJ	ENSUMUG00000029546	protein coding gene	Chr13:51758089-51765469 (+)
LP/J	ENSMUSG00230027722	protein coding gene	Chr13:61705432-61712824 (+)
NOD/ShiLtJ	ENSMUSG00190028737	protein coding gene	Chr13:51407964-51415351 (+)
NZO/HlLtJ	ENSMUSG00225033195	protein coding gene	Chr13:55432720-55440119 (+)
PWK/PhJ	ENSLUMG00010019316	protein coding gene	Chr13:50633354-50640742 (+)
SPRET/EiJ	ENSMSPG00010032898	protein coding gene	Chr13:51050604-51057980 (+)
WSB/EiJ	ENSIUOG00005024434	protein coding gene	Chr13:50834942-50842334 (+)

Human Ortholog

TSPAN17, tetraspanin 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSPAN17, tetraspanin 17
Synonyms

FBX23, FBXO23, TM4SF17
Links

HGNC:13594

NCBI Gene ID: 26262

UniProt: Q96FV3
Chr Location

5q35.2; chr5:176647387-176659058 (+) GRCh38

MGI Vertebrate Homology

Tspan17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSPAN17
Protein SuperFamily

Tetraspanin
Gene Tree

Tspan17

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

2 involving Tspan17
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

19
cDNA Data

37
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tspan17

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All Sequences

72
RefSeq

13
UniProt

11
CCDS

CCDS26536.1

Ensembl

ENSMUSG00000025875 (Evidence)
NCBI Gene

74257

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025875	Ensembl Gene Model \| MGI Sequence Detail	7400	C57BL/6J	± kb
transcript	ENSMUST00000131692	Ensembl \| MGI Sequence Detail	1048	Not Applicable
polypeptide	ENSMUSP00000115287	Ensembl \| MGI Sequence Detail	285	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000016743 tetraspanin-17

(term hierarchy)
InterPro Domains

IPR000301 Tetraspanin, animals

IPR018503 Tetraspanin, conserved site

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin
GlyGen

Q9D7W4 2 sites

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All nucleic 37

cDNA 37

Microarray probesets 3

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MGI:2145183

Summaries

All 43

Developmental Gene Expression 1

Diseases 1

Gene Ontology 7

Phenotypes 10
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tspan17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119900	Chr13:54937239-54937310 (+)	85 bp
Tssr119901	Chr13:54937313-54937322 (+)	128 bp
Tssr119902	Chr13:54937797-54937802 (+)	610 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24