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Ctbs Gene Detail
Summary
  • Symbol
    Ctbs
  • Name
    chitobiase
  • Synonyms
    2210401K11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921495
    NCBI Gene: 74245
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:146156204-146171604 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 71.26 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    505 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921495
 protein coding gene Chr3:146155550-146171604 (+)
129S1/SvImJ ENSMUSG00200003523
 protein coding gene Chr3:143074861-143091845 (+)
A/J ENSMUSG00195003253
 protein coding gene Chr3:143190300-143207317 (+)
AKR/J ENSMUSG00220000401
 protein coding gene Chr3:141602724-141619712 (+)
BALB/cJ ENSMUSG00180022985
 protein coding gene Chr3:143060698-143077722 (+)
C3H/HeJ ENSMUSG00175018356
 protein coding gene Chr3:142642712-142659723 (+)
C57BL/6NJ ENSMUSG00215009586
 protein coding gene Chr3:143342427-143359403 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025723
 protein coding gene Chr3:139642109-139658552 (+)
CAST/EiJ ENSTCUG00005000884
 protein coding gene Chr3:143732996-143755454 (+)
CBA/J ENSMUSG00210003598
 protein coding gene Chr3:143320092-143337105 (+)
DBA/2J ENSMUSG00185024969
 protein coding gene Chr3:143907840-143924833 (+)
FVB/NJ ENSMUSG00205017843
 protein coding gene Chr3:142182518-142199491 (+)
JF1/MsJ ENSUMUG00000029575
 protein coding gene Chr3:142711148-142726575 (+)
LP/J ENSMUSG00230017902
 protein coding gene Chr3:145828253-145845241 (+)
NOD/ShiLtJ ENSMUSG00190004022
 protein coding gene Chr3:144280417-144297427 (+)
NZO/HlLtJ ENSMUSG00225002466
 protein coding gene Chr3:148338778-148355749 (+)
PWK/PhJ ENSLUMG00010019525
 protein coding gene Chr3:142619936-142635332 (+)
SPRET/EiJ ENSMSPG00010007506
 protein coding gene Chr3:143922304-143937722 (+)
WSB/EiJ ENSIUOG00005014962
 protein coding gene Chr3:143370975-143387915 (+)



Homology
more
  • Human Ortholog
    CTBS, chitobiase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTBS, chitobiase
  • Synonyms
    CTB
  • Links
    NCBI Gene ID: 1486
    UniProt: Q01459

  • Chr Location
    1p22.3; chr1:84549611-84574480 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit accumulation of oligosaccharides.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    8
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74245 NCBI Gene Model | MGI Sequence Detail 15401 C57BL/6J ±  kb
    transcript NM_001293672 RefSeq | MGI Sequence Detail 2887 C57BL/6  
    polypeptide Q8R242 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005996 di-N-acetylchitobiase
      (term hierarchy)
    • EC
      3.2.1.-
    • InterPro Domains
      IPR011583 Chitinase II/V-like, catalytic domain
      IPR029070 Chitinase insertion domain superfamily
      IPR047898 Di-N-acetylchitobiase, catalytic domain
      IPR001223 Glycoside hydrolase family 18, catalytic domain
      IPR017853 Glycoside hydrolase superfamily
      IPR051887 Glycosyl Hydrolase 18 Domain-Containing Protein
      IPR001579 Glycosyl hydrolase family 18, active site
    • GlyGen
      Q8R242 7 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 6
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory