About   Help   FAQ
Acsl3 Gene Detail
Summary
  • Symbol
    Acsl3
  • Name
    acyl-CoA synthetase long-chain family member 3
  • Synonyms
    2610510B12Rik, C85929, Facl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921455
    NCBI Gene: 74205
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:78635600-78685462 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 40.84 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    262 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921455
protein coding gene Chr1:78635542-78685462 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016201
protein coding gene Chr1:79400333-79456192 (+)
A/J MGP_AJ_G0016184
protein coding gene Chr1:76621044-76670357 (+)
AKR/J MGP_AKRJ_G0016141
protein coding gene Chr1:78695881-78745858 (+)
BALB/cJ MGP_BALBcJ_G0016139
protein coding gene Chr1:76711048-76761213 (+)
C3H/HeJ MGP_C3HHeJ_G0015969
protein coding gene Chr1:79069597-79124261 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016592
protein coding gene Chr1:82441033-82505412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014312
protein coding gene Chr1:72044350-72099056 (+)
CAST/EiJ MGP_CASTEiJ_G0015554
protein coding gene Chr1:78453901-78513418 (+)
CBA/J MGP_CBAJ_G0015943
protein coding gene Chr1:85168626-85225167 (+)
DBA/2J MGP_DBA2J_G0016044
protein coding gene Chr1:75933125-75987071 (+)
FVB/NJ MGP_FVBNJ_G0016047
protein coding gene Chr1:75091733-75141510 (+)
LP/J MGP_LPJ_G0016116
protein coding gene Chr1:80529804-80583537 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016067
protein coding gene Chr1:88388803-88442436 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016639
protein coding gene Chr1:78844910-78897292 (+)
PWK/PhJ MGP_PWKPhJ_G0015340
protein coding gene Chr1:75402641-75454393 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015118
protein coding gene Chr1:78172817-78225727 (+)
WSB/EiJ MGP_WSBEiJ_G0015615
protein coding gene Chr1:78629898-78682657 (+)



Homology
more
  • Human Ortholog
    ACSL3, acyl-CoA synthetase long chain family member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACSL3, acyl-CoA synthetase long chain family member 3
  • Synonyms
    ACS3, FACL3, LACS3, LACS 3, PRO2194
  • Links
    NCBI Gene ID: 2181
    neXtProt AC: NX_O95573
    UniProt: O95573

  • Chr Location
    2q36.1; chr2:222860942-222944639 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with human ACSL3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice exhibit decreased blood percentages of CD4 T cells and B cells, and a decreased IgG1 response to ovalbumin. Male mutant mice exhibit growth retardation, reduced size and reduced total tissue and lean body mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74205 NCBI Gene Model | MGI Sequence Detail 49863 C57BL/6J ±  kb
    transcript NM_001409075 RefSeq | MGI Sequence Detail 3972 ZRU/MplStud  
    polypeptide Q9CZW4 UniProt | EBI | MGI Sequence Detail 720 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138711
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:347631 Li C, et al., Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    05/14/2024
    MGI 6.23
    The Jackson Laboratory