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Dtx2 Gene Detail
Summary
  • Symbol
    Dtx2
  • Name
    deltex 2, E3 ubiquitin ligase
  • Synonyms
    2610524D08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921448
    NCBI Gene: 74198
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136023654-136061726 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.64 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1074 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921448
 protein coding gene Chr5:136023654-136061735 (+)
129S1/SvImJ ENSMUSG00200041676
 protein coding gene Chr5:129809971-129848043 (+)
A/J ENSMUSG00195044672
 protein coding gene Chr5:129315606-129353766 (+)
AKR/J ENSMUSG00220045243
 protein coding gene Chr5:128811219-128849188 (+)
BALB/cJ ENSMUSG00180043677
 protein coding gene Chr5:129418613-129456773 (+)
C3H/HeJ ENSMUSG00175035938
 protein coding gene Chr5:131346362-131384518 (+)
C57BL/6NJ ENSMUSG00215045041
 protein coding gene Chr5:129465141-129503213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027848
 protein coding gene Chr5:128844711-128882341 (+)
CAST/EiJ ENSTCUG00005009990
 protein coding gene Chr5:128698350-128736734 (+)
CBA/J ENSMUSG00210007631
 protein coding gene Chr5:130163999-130202148 (+)
DBA/2J ENSMUSG00185051692
 protein coding gene Chr5:133179227-133217378 (+)
FVB/NJ ENSMUSG00205040450
 protein coding gene Chr5:129063638-129101795 (+)
JF1/MsJ ENSUMUG00000052413
 protein coding gene Chr5:136079566-136122516 (+)
LP/J ENSMUSG00230048744
 protein coding gene Chr5:137292812-137330968 (+)
NOD/ShiLtJ ENSMUSG00190042385
 protein coding gene Chr5:129118621-129156783 (+)
NZO/HlLtJ ENSMUSG00225023673
 protein coding gene Chr5:144974445-145012602 (+)
PWK/PhJ ENSLUMG00010015310
 protein coding gene Chr5:127918281-127956651 (+)
SPRET/EiJ ENSMSPG00010032690
 protein coding gene Chr5:131339097-131377613 (+)
WSB/EiJ ENSIUOG00005031591
 protein coding gene Chr5:131771615-131809773 (+)



Homology
more
  • Human Ortholog
    DTX2, deltex E3 ubiquitin ligase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DTX2, deltex E3 ubiquitin ligase 2
  • Synonyms
    RNF58
  • Links
    NCBI Gene ID: 113878
    UniProt: Q86UW9

  • Chr Location
    7q11.23; chr7:76461656-76506471 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    12 phenotype references
Mice homozygous for a knock-out allele are viable and overtly normal with no detectable abnormalities in T or B cell development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    794
  • Tissues
    44
  • cDNA Data
    76
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004947 Ensembl Gene Model | MGI Sequence Detail 38073 C57BL/6J ±  kb
transcript ENSMUST00000111142 Ensembl | MGI Sequence Detail 2650 Not Applicable  
polypeptide ENSMUSP00000106772 Ensembl | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 76
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140736, MGI:2141064
References
more
  • Summaries
    All 49
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:348702 Wang Q, et al., ASH2L Mediates Epidermal Differentiation and Hair Follicle Morphogenesis through H3K4me3 Modification. J Invest Dermatol. 2024 Apr 4;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory