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Muc5b Gene Detail
Summary
  • Symbol
    Muc5b
  • Name
    mucin 5, subtype B, tracheobronchial
  • Synonyms
    2300002I04Rik, MUC5, MUC9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921430
    NCBI Gene: 74180
  • Alliance
  • Transcription Start Sites
    35 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141392807-141426821 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 87.29 cM, cytoband F5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921430
protein coding gene Chr7:141392796-141426826 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0033156
protein coding gene Chr7:146783476-146831888 (+)
BALB/cJ MGP_BALBcJ_G0033224
protein coding gene Chr7:142545085-142585343 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033736
protein coding gene Chr7:152391275-152428653 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030709
protein coding gene Chr7:144011344-144044701 (+)
CAST/EiJ MGP_CASTEiJ_G0032269
protein coding gene Chr7:138841867-138879674 (+)
CBA/J MGP_CBAJ_G0032911
protein coding gene Chr7:157550764-157595295 (+)
DBA/2J MGP_DBA2J_G0033063
protein coding gene Chr7:140756373-140788514 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0033158
protein coding gene Chr7:148515091-148553974 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033049
protein coding gene Chr7:158184555-158228070 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0031973
protein coding gene Chr7:134048985-134086050 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031819
protein coding gene Chr7:132567454-132598911 (+)
WSB/EiJ MGP_WSBEiJ_G0032379
protein coding gene Chr7:146729192-146739140 (+)



Homology
more
  • Human Ortholog
    MUC5B, mucin 5B, oligomeric mucus/gel-forming
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MUC5B, mucin 5B, oligomeric mucus/gel-forming
  • Synonyms
    MG1, MUC5, MUC-5B, MUC9
  • Links
    NCBI Gene ID: 727897
    neXtProt AC: NX_Q9HC84
    UniProt: Q9HC84

  • Chr Location
    11p15.5; chr11:1223066-1262172 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with human MUC5B associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele accumulate materials in the upper and lower airways leading to chronic infection and inflammation that does not resolve and results in premature death. Macrophage function is impaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066108 Ensembl Gene Model | MGI Sequence Detail 34015 C57BL/6J ±  kb
    transcript ENSMUST00000165147 Ensembl | MGI Sequence Detail 14964 Not Applicable  
    polypeptide ENSMUSP00000128276 Ensembl | MGI Sequence Detail 4800 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142176
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 24
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:342039 Huang X, et al., MUC5B regulates goblet cell differentiation and reduces inflammation in a murine COPD model. Respir Res. 2022 Jan 18;23(1):11

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory