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Zdhhc16 Gene Detail
Summary
  • Symbol
    Zdhhc16
  • Name
    zinc finger, DHHC domain containing 16
  • Synonyms
    1500015N03Rik, Abl-philin 2, Ablphilin 2, APH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921418
    NCBI Gene: 74168
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41921919-41932543 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 35.48 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    325 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921418
 protein coding gene Chr19:41921884-41932543 (+)
129S1/SvImJ ENSMUSGG00200054639
 protein coding gene Chr19:38662058-38662686 (+)
129S1/SvImJ ENSMUSG00200025892
 protein coding gene Chr19:38658026-38661152 (+)
A/J ENSMUSG00195010178
 protein coding gene Chr19:38762762-38765889 (+)
A/J ENSMUSGG00195055390
 protein coding gene Chr19:38766795-38767423 (+)
AKR/J ENSMUSGG00220054618
 protein coding gene Chr19:38578846-38579474 (+)
AKR/J ENSMUSG00220018040
 protein coding gene Chr19:38574814-38577940 (+)
BALB/cJ ENSMUSG00180028245
 protein coding gene Chr19:39015173-39018300 (+)
BALB/cJ ENSMUSGG00180055319
 protein coding gene Chr19:39019206-39019834 (+)
C3H/HeJ ENSMUSG00175038207
 protein coding gene Chr19:38537026-38540152 (+)
C3H/HeJ ENSMUSGG00175054760
 protein coding gene Chr19:38541058-38541686 (+)
C57BL/6NJ ENSMUSGG00215055753
 protein coding gene Chr19:38619560-38620165 (+)
C57BL/6NJ ENSMUSG00215023196
 protein coding gene Chr19:38615544-38618654 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022960
 protein coding gene Chr19:38608645-38618615 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210031262
 protein coding gene Chr19:38619154-38622280 (+)
CBA/J ENSMUSGG00210054474
 protein coding gene Chr19:38623186-38623814 (+)
DBA/2J ENSMUSGG00185057931
 protein coding gene Chr19:39143359-39143987 (+)
DBA/2J ENSMUSG00185032217
 protein coding gene Chr19:39139327-39142453 (+)
FVB/NJ ENSMUSG00205006466
 protein coding gene Chr19:38089873-38092999 (+)
FVB/NJ ENSMUSGG00205054295
 protein coding gene Chr19:38093905-38094533 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055591
 protein coding gene Chr19:39932152-39932780 (+)
LP/J ENSMUSG00230034043
 protein coding gene Chr19:39928120-39931246 (+)
NOD/ShiLtJ ENSMUSG00190010970
 protein coding gene Chr19:38489133-38492259 (+)
NOD/ShiLtJ ENSMUSGG00190054761
 protein coding gene Chr19:38493165-38493793 (+)
NZO/HlLtJ ENSMUSG00225041672
 protein coding gene Chr19:43486162-43489288 (+)
NZO/HlLtJ ENSMUSGG00225055379
 protein coding gene Chr19:43490194-43490822 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ZDHHC16, zDHHC palmitoyltransferase 16
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDHHC16, zDHHC palmitoyltransferase 16
  • Synonyms
    APH2, DHHC-16
  • Links
    NCBI Gene ID: 84287
    UniProt: Q969W1

  • Chr Location
    10q24.1; chr10:97446142-97457370 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display prenatal and neonatal lethality with bradycardia, abnormal heart morphology and eye defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    26
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025157 Ensembl Gene Model | MGI Sequence Detail 10625 C57BL/6J ±  kb
    transcript ENSMUST00000026154 Ensembl | MGI Sequence Detail 1821 Not Applicable  
    polypeptide ENSMUSP00000026154 Ensembl | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory