Acbd5 MGI Mouse Gene Detail - MGI:1921409 - acyl-Coenzyme A binding domain containing 5

Symbol

Acbd5
Name

acyl-Coenzyme A binding domain containing 5
Synonyms

1300014E15Rik

Feature Type

protein coding gene
IDs

MGI:1921409
NCBI Gene: 74159
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:22958189-23004525 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 15.21 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

1299 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921409	protein coding gene	Chr2:22958179-23005570 (+)
129S1/SvImJ	ENSMUSG00200041072	protein coding gene	Chr2:19936085-19983487 (+)
A/J	ENSMUSG00195016560	protein coding gene	Chr2:20031400-20078795 (+)
AKR/J	ENSMUSG00220052119	protein coding gene	Chr2:20152584-20199982 (+)
BALB/cJ	ENSMUSG00180036933	protein coding gene	Chr2:20037234-20084634 (+)
C3H/HeJ	ENSMUSG00175021028	protein coding gene	Chr2:20001862-20049254 (+)
C57BL/6NJ	ENSMUSG00215029039	protein coding gene	Chr2:20061610-20109012 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023226	protein coding gene	Chr2:19052226-19101123 (+)
CAST/EiJ	ENSTCUG00005004089	protein coding gene	Chr2:19764447-19812291 (+)
CBA/J	ENSMUSG00210003385	protein coding gene	Chr2:20040836-20088235 (+)
DBA/2J	ENSMUSG00185037866	protein coding gene	Chr2:19945752-19993138 (+)
FVB/NJ	ENSMUSG00205010436	protein coding gene	Chr2:19960503-20007931 (+)
JF1/MsJ	ENSUMUG00000003787	protein coding gene	Chr2:19832182-19888925 (+)
LP/J	ENSMUSG00230036499	protein coding gene	Chr2:21872054-21919447 (+)
NOD/ShiLtJ	ENSMUSG00190014475	protein coding gene	Chr2:20031797-20079186 (+)
NZO/HlLtJ	ENSMUSG00225001248	protein coding gene	Chr2:29622676-29670071 (+)
PWK/PhJ	ENSLUMG00010032540	protein coding gene	Chr2:19934454-19982388 (+)
SPRET/EiJ	ENSMSPG00010044143	protein coding gene	Chr2:20520723-20568716 (+)
WSB/EiJ	ENSIUOG00005015144	protein coding gene	Chr2:19851297-19898716 (+)

Human Ortholog

ACBD5, acyl-CoA binding domain containing 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACBD5, acyl-CoA binding domain containing 5
Synonyms

RDLKD
Links

HGNC:23338

NCBI Gene ID: 91452

UniProt: Q5T8D3
Chr Location

10p12.1; chr10:27168135-27243046 (-) GRCh38

MGI Vertebrate Homology

Acbd5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ACBD5
Protein SuperFamily

MA_DBI
Gene Tree

Acbd5

Diseases

1 with Acbd5 mouse models; 1 with human ACBD5 associations

Human Disease

Mouse Models

retinal dystrophy with leukodystrophy

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

42 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Endonuclease-mediated

3
Gene trapped

11
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit alternations in cellular lipid homeostasis in the cerebellum and liver with increased very long-chain fatty acid levels, progressive cerebellar degeneration, peroxisome abnormalities, ataxia, and develop a peroxisome disorder.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

680
Tissues

13
cDNA Data

9
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acbd5

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All Sequences

124
RefSeq

49
UniProt

8
CCDS

CCDS50514.1, CCDS50515.1, CCDS50516.1, CCDS57156.1, CCDS89434.1, CCDS89435.1, CCDS89437.1

Ensembl

ENSMUSG00000026781 (Evidence)
NCBI Gene

74159

			Length	Strain/Species	Flank
genomic	74159	NCBI Gene Model \| MGI Sequence Detail	46337	C57BL/6J	± kb
transcript	NM_001355637	RefSeq \| MGI Sequence Detail	3757	C57BL/6
polypeptide	Q5XG73	UniProt \| EBI \| MGI Sequence Detail	508	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000032706 acyl-CoA-binding domain-containing protein 5

(term hierarchy)
InterPro Domains

IPR016347 Acyl-CoA-binding domain-containing protein 5

IPR000582 Acyl-CoA-binding protein, ACBP

IPR022408 Acyl-CoA-binding protein, ACBP, conserved site

IPR035984 Acyl-CoA binding protein superfamily

IPR014352 FERM/acyl-CoA-binding protein superfamily
GlyGen

Q5XG73 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 4

Summaries

All 38

Developmental Gene Expression 3

Diseases 1

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Acbd5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16529	Chr2:22958229-22958253 (+)	52 bp
Tssr16530	Chr2:22958273-22958296 (+)	96 bp
Tssr16531	Chr2:22959069-22959101 (+)	896 bp
Tssr16532	Chr2:22959129-22959156 (+)	954 bp
Tssr16533	Chr2:22959161-22959181 (+)	982 bp
Tssr16534	Chr2:22959200-22959220 (+)	1,021 bp
Tssr16535	Chr2:22959222-22959264 (+)	1,054 bp
Tssr16536	Chr2:22959425-22959436 (+)	1,242 bp
Tssr16537	Chr2:22959453-22959467 (+)	1,271 bp
Tssr16538	Chr2:22988101-22988105 (+)	29,914 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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