Abtb3 MGI Mouse Gene Detail - MGI:1921257 - ankyrin repeat and BTB domain containing 3

Symbol

Abtb3
Name

ankyrin repeat and BTB domain containing 3
Synonyms

6330404E16Rik, Btbd11

Feature Type

protein coding gene
IDs

MGI:1921257
NCBI Gene: 74007
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:85222678-85496156 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.65 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

8278 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921257	protein coding gene	Chr10:85220835-85496156 (+)
129S1/SvImJ	ENSMUSG00200026988	protein coding gene	Chr10:81715868-81990407 (+)
A/J	ENSMUSG00195020831	protein coding gene	Chr10:82171005-82440281 (+)
AKR/J	ENSMUSG00220020109	protein coding gene	Chr10:81773328-82042587 (+)
BALB/cJ	ENSMUSG00180029872	protein coding gene	Chr10:82174118-82443401 (+)
C3H/HeJ	ENSMUSG00175022166	protein coding gene	Chr10:82050009-82319269 (+)
C57BL/6NJ	ENSMUSG00215022246	protein coding gene	Chr10:81713170-81987719 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015684	protein coding gene	Chr10:79242233-79515394 (+)
CAST/EiJ	ENSTCUG00005050265	protein coding gene	Chr10:81490635-81760687 (+)
CBA/J	ENSMUSG00210031346	protein coding gene	Chr10:81900745-82169999 (+)
DBA/2J	ENSMUSG00185052700	protein coding gene	Chr10:82109051-82389863 (+)
FVB/NJ	ENSMUSG00205050602	protein coding gene	Chr10:81823481-82092748 (+)
JF1/MsJ	ENSUMUG00000021712	protein coding gene	Chr10:83503264-83774733 (+)
LP/J	ENSMUSG00230015486	protein coding gene	Chr10:84012507-84282408 (+)
NOD/ShiLtJ	ENSMUSG00190046963	protein coding gene	Chr10:82156700-82425957 (+)
NZO/HlLtJ	ENSMUSG00225051517	protein coding gene	Chr10:88279990-88549220 (+)
PWK/PhJ	ENSLUMG00010022646	protein coding gene	Chr10:81784129-82053987 (+)
SPRET/EiJ	ENSMSPG00010030728	protein coding gene	Chr10:83222642-83489809 (+)
WSB/EiJ	ENSIUOG00005035586	protein coding gene	Chr10:81873402-82143724 (+)

Human Ortholog

ABTB3, ankyrin repeat and BTB domain containing 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ABTB3, ankyrin repeat and BTB domain containing 3
Synonyms

ABTB2B, BTBD11
Links

HGNC:23844

NCBI Gene ID: 121551

UniProt: A6QL63
Chr Location

12q23.3; chr12:107318421-107659642 (+) GRCh38

MGI Vertebrate Homology

Abtb3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ABTB3
Gene Tree

Abtb3

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

36
Targeted

3
Genomic Mutations

1 involving Abtb3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

151 strains or lines available

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All GO Annotations

15
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

51
cDNA Data

42
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA BTBD11

Xenbase abtb3

ZFIN abtb3b

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All Sequences

53
RefSeq

6
UniProt

5
CCDS

CCDS24091.2, CCDS36018.1

Ensembl

ENSMUSG00000020042 (Evidence)
NCBI Gene

74007

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020042	Ensembl Gene Model \| MGI Sequence Detail	273479	C57BL/6J	± kb
transcript	ENSMUST00000105307	Ensembl \| MGI Sequence Detail	5788	Not Applicable
polypeptide	ENSMUSP00000100944	Ensembl \| MGI Sequence Detail	1109	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000031621 ankyrin repeat- and BTB/POZ domain-containing protein 3

(term hierarchy)
InterPro Domains

IPR059008 ABTB2/3, histone-like domain

IPR002110 Ankyrin repeat

IPR052089 Ankyrin repeat and BTB/POZ domain-containing protein

IPR036770 Ankyrin repeat-containing domain superfamily

IPR000210 BTB/POZ domain

IPR047824 BTB/POZ domain-containing protein 11, BACK domain

IPR009072 Histone-fold

IPR011333 SKP1/BTB/POZ domain superfamily
GlyGen

Q6GQW0 2 sites, 1 N-linked glycan (1 site)

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All nucleic 42

cDNA 42

Microarray probesets 3

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MGI:7336156

Summaries

All 51

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:390447 Yamada T, et al., Gene regulatory innovations from transposable elements in primate cerebellum development. Nat Commun. 2026 Jul 30;17(1)

TSS for Abtb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94928	Chr10:85222677-85222710 (+)	16 bp
Tssr94929	Chr10:85222712-85222724 (+)	40 bp
Tssr94930	Chr10:85374447-85374491 (+)	151,791 bp
Tssr94931	Chr10:85376028-85376066 (+)	153,369 bp
Tssr94932	Chr10:85434590-85434619 (+)	211,927 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24