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Tmco1 Gene Detail
Summary
  • Symbol
    Tmco1
  • Name
    transmembrane and coiled-coil domains 1
  • Synonyms
    1190006A08Rik, 4930403O06Rik, ESTM39
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921173
    NCBI Gene: 68944
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:167136239-167161547 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 74.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921173
 protein coding gene Chr1:167135947-167161547 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016712
 protein coding gene Chr1:172866099-172892205 (+)
A/J MGP_AJ_G0016692
 protein coding gene Chr1:165816499-165842860 (+)
AKR/J MGP_AKRJ_G0016658
 protein coding gene Chr1:170826454-170853987 (+)
BALB/cJ MGP_BALBcJ_G0016653
 protein coding gene Chr1:166297136-166329080 (+)
C3H/HeJ MGP_C3HHeJ_G0016477
 protein coding gene Chr1:171059562-171087166 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017114
 protein coding gene Chr1:178663063-178688052 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014823
 protein coding gene Chr1:157662051-157689940 (+)
CAST/EiJ MGP_CASTEiJ_G0016057
 protein coding gene Chr1:170668708-170694687 (+)
CBA/J MGP_CBAJ_G0016452
 protein coding gene Chr1:184995364-185029868 (+)
DBA/2J MGP_DBA2J_G0016558
 protein coding gene Chr1:164661192-164688039 (+)
FVB/NJ MGP_FVBNJ_G0016556
 protein coding gene Chr1:163108953-163136185 (+)
LP/J MGP_LPJ_G0016629
 protein coding gene Chr1:173941963-173969107 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016581
 protein coding gene Chr1:192389307-192423986 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017151
 protein coding gene Chr1:170696608-170726292 (+)
PWK/PhJ MGP_PWKPhJ_G0015843
 protein coding gene Chr1:163866470-163893489 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015629
 protein coding gene Chr1:169475600-169502862 (+)
WSB/EiJ MGP_WSBEiJ_G0016119
 protein coding gene Chr1:170791774-170827702 (+)



Homology
more
  • Human Ortholog
    TMCO1, transmembrane and coiled-coil domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMCO1, transmembrane and coiled-coil domains 1
  • Synonyms
    CFSMR1, HP10122, PCIA3, PNAS-136, TMCC4
  • Links
    NCBI Gene ID: 54499
    neXtProt AC: NX_Q9UM00
    UniProt: Q9UM00

  • Chr Location
    1q24.1; chr1:165724291-165827755 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tmco1 mouse models; 1 with human TMCO1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show prenatal lethality, stunted growth, delayed osteogenesis, craniofacial anomalies, impaired coordination and spatial memory, altered Ca2+ homeostasis, and reduced survivor rate. Homozygotes for another null allele show female subfertility, impaired ovarian folliculogenesis, premature ovarian failure, and altered endoplasmic reticulum Ca2+ homeostasis in granulosa cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    4
  • cDNA Data
    110
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68944 NCBI Gene Model | MGI Sequence Detail 25309 C57BL/6J ±  kb
    transcript NM_001039483 RefSeq | MGI Sequence Detail 4474 C57BL/6  
    polypeptide Q921L3 UniProt | EBI | MGI Sequence Detail 188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      cDNA 110
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1334461, MGI:1916194, MGI:2138472
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:327333 Yang KY, et al., Ca(2+) homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling. Cell Death Dis. 2022 Aug 4;13(8):674
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory