Ankrd45 MGI Mouse Gene Detail - MGI:1921094

Symbol

Ankrd45
Name

ankyrin repeat domain 45
Synonyms

4933409K03Rik

Feature Type

protein coding gene
IDs

MGI:1921094
NCBI Gene: 73844
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:160970261-160998068 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 69.75 cM, cytoband H1
Mapping Data

2 experiments

SNPs within 2kb

704 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921094	protein coding gene	Chr1:160970017-160998077 (+)
129S1/SvImJ	ENSMUSG00200005801	protein coding gene	Chr1:158466126-158493386 (+)
A/J	ENSMUSG00195022113	protein coding gene	Chr1:157791440-157818607 (+)
AKR/J	ENSMUSG00220013677	protein coding gene	Chr1:157580906-157608712 (+)
BALB/cJ	ENSMUSG00180035555	protein coding gene	Chr1:158027399-158054917 (+)
C3H/HeJ	ENSMUSG00175036658	protein coding gene	Chr1:158101345-158128606 (+)
C57BL/6NJ	ENSMUSG00215034031	protein coding gene	Chr1:157989169-158016975 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014762	protein coding gene	Chr1:151750713-151778282 (+)
CAST/EiJ	ENSTCUG00005019792	protein coding gene	Chr1:156624623-156652159 (+)
CBA/J	ENSMUSG00210021048	protein coding gene	Chr1:157999096-158026357 (+)
DBA/2J	ENSMUSG00185040721	protein coding gene	Chr1:162245522-162273044 (+)
FVB/NJ	ENSMUSG00205009706	protein coding gene	Chr1:157075952-157103759 (+)
JF1/MsJ	ENSUMUG00000020363	protein coding gene	Chr1:161406265-161433787 (+)
LP/J	ENSMUSG00230011683	protein coding gene	Chr1:161867458-161894720 (+)
NOD/ShiLtJ	ENSMUSG00190033512	protein coding gene	Chr1:157827747-157855552 (+)
NZO/HlLtJ	ENSMUSG00225004358	protein coding gene	Chr1:165477099-165504907 (+)
PWK/PhJ	ENSLUMG00010036068	protein coding gene	Chr1:156786286-156813790 (+)
SPRET/EiJ	ENSMSPG00010041551	protein coding gene	Chr1:160196720-160224687 (+)
WSB/EiJ	ENSIUOG00005015227	protein coding gene	Chr1:157386441-157414254 (+)

Human Ortholog

ANKRD45, ankyrin repeat domain 45

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANKRD45, ankyrin repeat domain 45
Synonyms

CT117
Links

HGNC:24786

NCBI Gene ID: 339416

UniProt: Q5TZF3
Chr Location

1q25.1; chr1:173608336-173715185 (-) GRCh38

MGI Vertebrate Homology

Ankrd45 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANKRD45
Gene Tree

Ankrd45

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

16
Targeted

2
Genomic Mutations

2 involving Ankrd45
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

16
GO References

4

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ankrd45

ZFIN ankrd45

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All Sequences

63
RefSeq

22
UniProt

6
CCDS

CCDS48414.1, CCDS87902.1

Ensembl

ENSMUSG00000044835 (Evidence)
NCBI Gene

73844

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044835	Ensembl Gene Model \| MGI Sequence Detail	27808	C57BL/6J	± kb
transcript	ENSMUST00000052245	Ensembl \| MGI Sequence Detail	849	Not Applicable
polypeptide	ENSMUSP00000059923	Ensembl \| MGI Sequence Detail	282	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000031737 ankyrin repeat domain-containing protein 45

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR050776 Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor

IPR036770 Ankyrin repeat-containing domain superfamily

IPR029048 Heat shock protein 70kD, C-terminal domain superfamily

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 36

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ankrd45:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9680	Chr1:160970231-160970271 (+)	-10 bp
Tssr9681	Chr1:160970276-160970314 (+)	34 bp
Tssr9682	Chr1:160978554-160978558 (+)	8,295 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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