Chct1 Gene Detail

Summary

• Symbol
  Chct1
• Name
  CHD1 helical C-terminal domain containing 1
• Synonyms
  1700125H20Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1920884
  NCBI Gene: 73634
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr11:85061230-85071971 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 51.34 cM, cytoband B5
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  120 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920884	protein coding gene	Chr11:85031023-85072042 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018879	protein coding gene	Chr11:86657902-86669944 (+)
A/J	MGP_AJ_G0018846	protein coding gene	Chr11:83334517-83346874 (+)
AKR/J	MGP_AKRJ_G0018816	protein coding gene	Chr11:85816123-85826995 (+)
BALB/cJ	MGP_BALBcJ_G0018819	protein coding gene	Chr11:83723693-83737695 (+)
C3H/HeJ	MGP_C3HHeJ_G0018633	protein coding gene	Chr11:85856230-85866687 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019271	protein coding gene	Chr11:89275244-89303505 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016904	protein coding gene	Chr11:80397620-80407937 (+)
CAST/EiJ	MGP_CASTEiJ_G0018188	protein coding gene	Chr11:86503219-86514321 (+)
CBA/J	MGP_CBAJ_G0018604	protein coding gene	Chr11:93084193-93098695 (+)
DBA/2J	MGP_DBA2J_G0018712	protein coding gene	Chr11:82912729-82923632 (+)
FVB/NJ	MGP_FVBNJ_G0018701	protein coding gene	Chr11:82397751-82408189 (+)
LP/J	MGP_LPJ_G0018782	protein coding gene	Chr11:87163458-87173887 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018728	protein coding gene	Chr11:93221771-93231985 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019311	protein coding gene	Chr11:86076059-86087754 (+)
PWK/PhJ	MGP_PWKPhJ_G0017957	protein coding gene	Chr11:83687229-83697737 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017749	protein coding gene	Chr11:85634283-85647587 (+)
WSB/EiJ	MGP_WSBEiJ_G0018239	protein coding gene	Chr11:85926276-85936761 (+)

Homology

• Human Ortholog
  CHCT1, CHD1 helical C-terminal domain containing 1

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CHCT1, CHD1 helical C-terminal domain containing 1
  
• Synonyms
  C17orf64
• Links
  HGNC:26990

  NCBI Gene ID: 124773

  neXtProt AC: NX_Q86WR6

  UniProt: Q86WR6

  
  
• Chr Location
  17q23.2; chr17:60392429-60431426 (+)  GRCh38

---

• MGI Vertebrate Homology
  Chct1 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: CHCT1
• Gene Tree
  Chct1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 1 allele in 2 genetic backgrounds
  17 phenotype references
  

• All Mutations and Alleles
  40
• Chemically induced (other)
  1
• Gene trapped
  35
• Targeted
  4
• Genomic Mutations
  2 involving Chct1
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  15 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Male mice homozygous for a mutation are viable and show normal fertility.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  1
• GO References
  1

Expression

• Assay Results
  708
• Tissues
  2
• cDNA Data
  5
• Literature Summary
  1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  50
• RefSeq
  20
• UniProt
  1
• CCDS
  CCDS48872.1

• Ensembl
  ENSMUSG00000018479 (Evidence)
• NCBI Gene
  73634

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000018479	Ensembl Gene Model | MGI Sequence Detail	10742	C57BL/6J
transcript	ENSMUST00000018623	Ensembl | MGI Sequence Detail	966	Not Applicable
polypeptide	ENSMUSP00000018623	Ensembl | MGI Sequence Detail	236	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000059904 CHD1 helical C-terminal domain containing protein 1
  (term hierarchy)
• InterPro Domains
  IPR039880 CHD1 helical C-terminal domain containing protein 1-like
  IPR025260 Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain

Molecular
Reagents

• All nucleic 5

  cDNA 5

  
  

  Microarray probesets 4

References

• Summaries
  All 39

  Developmental Gene Expression 1

  Gene Ontology 1

  Phenotypes 17
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Chct1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3620	Chr11:85061894-85061899 (+)	667 bp
Tssr103818	Chr11:85061900-85061912 (+)	676 bp
Tssr103819	Chr11:85061923-85061930 (+)	697 bp
Tssr3621	Chr11:85068824-85068837 (+)	7,601 bp
Tssr103820	Chr11:85068860-85068867 (+)	7,634 bp