Mbd3l1 MGI Mouse Gene Detail - MGI:1920753 - methyl-CpG binding domain protein 3-like 1

Symbol

Mbd3l1
Name

methyl-CpG binding domain protein 3-like 1
Synonyms

1700070G05Rik, 1700095H13Rik, Mbd3l

Feature Type

protein coding gene
IDs

MGI:1920753
NCBI Gene: 73503
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:18389655-18396594 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 7.06 cM, cytoband A3
Mapping Data

2 experiments

SNPs within 2kb

218 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920753	protein coding gene	Chr9:18389655-18396594 (+)
129S1/SvImJ	ENSMUSG00200049031	protein coding gene	Chr9:15255883-15262838 (+)
A/J	ENSMUSG00195032579	protein coding gene	Chr9:15179561-15186500 (+)
AKR/J	ENSMUSG00220029646	protein coding gene	Chr9:15158078-15165019 (+)
BALB/cJ	ENSMUSG00180039683	protein coding gene	Chr9:15307616-15314557 (+)
C3H/HeJ	ENSMUSG00175039116	protein coding gene	Chr9:15276336-15283273 (+)
C57BL/6NJ	ENSMUSG00215030796	protein coding gene	Chr9:15269320-15276257 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031808	protein coding gene	Chr9:14461748-14467870 (+)
CAST/EiJ	ENSTCUG00005031063	protein coding gene	Chr9:15205125-15212168 (+)
CBA/J	ENSMUSG00210039476	protein coding gene	Chr9:15257627-15264572 (+)
DBA/2J	ENSMUSG00185022845	protein coding gene	Chr9:15373033-15379972 (+)
FVB/NJ	ENSMUSG00205022225	protein coding gene	Chr9:15487536-15494481 (+)
JF1/MsJ	ENSUMUG00000035426	protein coding gene	Chr9:15333397-15340289 (+)
LP/J	ENSMUSG00230036848	protein coding gene	Chr9:15754056-15760999 (+)
NOD/ShiLtJ	ENSMUSG00190033803	protein coding gene	Chr9:15288468-15295407 (+)
NZO/HlLtJ	ENSMUSG00225050491	protein coding gene	Chr9:15642258-15649205 (+)
PWK/PhJ	ENSLUMG00010044105	protein coding gene	Chr9:15289001-15295894 (+)
SPRET/EiJ	ENSMSPG00010022740	protein coding gene	Chr9:15509524-15516370 (+)
WSB/EiJ	ENSIUOG00005039427	protein coding gene	Chr9:14821721-14828686 (+)

Human Ortholog

MBD3L1, methyl-CpG binding domain protein 3 like 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MBD3L1, methyl-CpG binding domain protein 3 like 1
Synonyms

MBD3L
Links

HGNC:15774

NCBI Gene ID: 85509

UniProt: Q8WWY6
Chr Location

19p13.2; chr19:8832377-8843340 (+) GRCh38

MGI Vertebrate Homology

Mbd3l1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MBD3L1
Gene Tree

Mbd3l1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
2 phenotype references

All Mutations and Alleles

1
Targeted

1
Find Mice (IMSR)

14 strains or lines available

Homozygous null mice are viable and fertile.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

10

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

6
UniProt

2
CCDS

CCDS22845.1

Ensembl

ENSMUSG00000038691 (Evidence)
NCBI Gene

73503

			Length	Strain/Species	Flank
genomic	73503	NCBI Gene Model \| MGI Sequence Detail	6940	C57BL/6J	± kb
transcript	NM_028557	RefSeq \| MGI Sequence Detail	888	C57BL/6
polypeptide	Q9D9H3	UniProt \| EBI \| MGI Sequence Detail	186	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010217 methyl-CpG-binding domain protein 3-like 1

(term hierarchy)
InterPro Domains

IPR032343 Methyl-CpG-binding domain protein 2/3, p55-binding region

IPR025884 Methyl-CpG binding protein 2/3, C-terminal domain

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All nucleic 10

cDNA 10

Microarray probesets 3

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MGI:1925722

Summaries

All 27

Gene Ontology 4

Phenotypes 2
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:156017 Yokoyama S, et al., A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48

TSS for Mbd3l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83887	Chr9:18389633-18389640 (+)	-18 bp
Tssr83888	Chr9:18389643-18389646 (+)	-10 bp
Tssr83889	Chr9:18389655-18389657 (+)	1 bp
Tssr83890	Chr9:18389659-18389673 (+)	11 bp
Tssr83891	Chr9:18389678-18389697 (+)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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