Bpifa3 MGI Mouse Gene Detail - MGI:1920638 - BPI fold containing family A, member 3

Symbol

Bpifa3
Name

BPI fold containing family A, member 3
Synonyms

1700058C13Rik

Feature Type

protein coding gene
IDs

MGI:1920638
NCBI Gene: 73388
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:153972256-153980276 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 76.15 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

182 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920638	protein coding gene	Chr2:153972222-153980279 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026706	protein coding gene	Chr2:158850613-158858621 (+)
A/J	MGP_AJ_G0026672	protein coding gene	Chr2:152455832-152463779 (+)
AKR/J	MGP_AKRJ_G0026643	protein coding gene	Chr2:156938784-156946809 (+)
BALB/cJ	MGP_BALBcJ_G0026682	protein coding gene	Chr2:152807763-152815788 (+)
C3H/HeJ	MGP_C3HHeJ_G0026424	protein coding gene	Chr2:157320002-157328040 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027131	protein coding gene	Chr2:163474350-163482360 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024501	protein coding gene	Chr2:146053835-146062694 (+)
CAST/EiJ	MGP_CASTEiJ_G0025885	protein coding gene	Chr2:157642070-157650100 (+)
CBA/J	MGP_CBAJ_G0026403	protein coding gene	Chr2:169474056-169482093 (+)
DBA/2J	MGP_DBA2J_G0026538	protein coding gene	Chr2:151719882-151727829 (+)
FVB/NJ	MGP_FVBNJ_G0026504	protein coding gene	Chr2:150125880-150133890 (+)
LP/J	MGP_LPJ_G0026643	protein coding gene	Chr2:158950545-158958553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026526	protein coding gene	Chr2:173503279-173511226 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027186	protein coding gene	Chr2:156820166-156828188 (+)
PWK/PhJ	MGP_PWKPhJ_G0025619	protein coding gene	Chr2:151274695-151282686 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025422	protein coding gene	Chr2:155761911-155769942 (+)
WSB/EiJ	MGP_WSBEiJ_G0025955	protein coding gene	Chr2:157738959-157747035 (+)

Human Ortholog

BPIFA3, BPI fold containing family A member 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BPIFA3, BPI fold containing family A member 3
Synonyms

C20orf71, SPLUNC3
Links

HGNC:16204

NCBI Gene ID: 128861

neXtProt AC: NX_Q9BQP9

UniProt: Q9BQP9
Chr Location

20q11.21; chr20:33217310-33227806 (+) GRCh38

MGI Vertebrate Homology

Bpifa3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BPIFA3
Gene Tree

Bpifa3

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Male mice homozygous for a null allele exhibit normal fecundity.

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

9
UniProt

3
CCDS

CCDS16924.1, CCDS71163.1

Ensembl

ENSMUSG00000027482 (Evidence)
NCBI Gene

73388

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027482	Ensembl Gene Model \| MGI Sequence Detail	8021	C57BL/6J	± kb
transcript	ENSMUST00000028984	Ensembl \| MGI Sequence Detail	1107	Not Applicable
polypeptide	ENSMUSP00000028984	Ensembl \| MGI Sequence Detail	239	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000015549 BPI fold-containing family A member 3

(term hierarchy)
InterPro Domains

IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily

IPR032946 BPI fold-containing family A member 3

IPR017942 Lipid-binding serum glycoprotein, N-terminal

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All nucleic 7

cDNA 7

Microarray probesets 3

Summaries

All 29

Gene Ontology 2

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Bpifa3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20967	Chr2:153972252-153972276 (+)	8 bp
Tssr20968	Chr2:153972287-153972294 (+)	35 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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