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Timm21 Gene Detail
Summary
  • Symbol
    Timm21
  • Name
    translocase of inner mitochondrial membrane 21
  • Synonyms
    1700034H14Rik, 2700002I20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920595
    NCBI Gene: 67105
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:84964316-84969649 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 57.53 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    225 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920595
 protein coding gene Chr18:84964316-84970168 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024612
 protein coding gene Chr18:86118036-86122256 (-)
A/J MGP_AJ_G0024579
 protein coding gene Chr18:82345478-82349708 (-)
AKR/J MGP_AKRJ_G0024550
 protein coding gene Chr18:84795340-84799570 (-)
BALB/cJ MGP_BALBcJ_G0024577
 protein coding gene Chr18:82537028-82541258 (-)
C3H/HeJ MGP_C3HHeJ_G0024346
 protein coding gene Chr18:84900985-84905215 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025024
 protein coding gene Chr18:88273079-88277309 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022454
 protein coding gene Chr18:81031828-81036227 (-)
CAST/EiJ MGP_CASTEiJ_G0023819
 protein coding gene Chr18:85297216-85302230 (-)
CBA/J MGP_CBAJ_G0024316
 protein coding gene Chr18:91459384-91463520 (-)
DBA/2J MGP_DBA2J_G0024445
 protein coding gene Chr18:81862992-81867222 (-)
FVB/NJ MGP_FVBNJ_G0024412
 protein coding gene Chr18:81199460-81203690 (-)
LP/J MGP_LPJ_G0024530
 protein coding gene Chr18:85925665-85930032 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024442
 protein coding gene Chr18:92712942-92717175 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025073
 protein coding gene Chr18:85022369-85026605 (-)
PWK/PhJ MGP_PWKPhJ_G0023564
 protein coding gene Chr18:82280294-82284654 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023370
 protein coding gene Chr18:85036949-85041236 (-)
WSB/EiJ MGP_WSBEiJ_G0023881
 protein coding gene Chr18:84967531-84973236 (-)



Homology
more
  • Human Ortholog
    TIMM21, translocase of inner mitochondrial membrane 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMM21, translocase of inner mitochondrial membrane 21
  • Synonyms
    C18orf55, HSPC154, TIM21
  • Links
    NCBI Gene ID: 29090
    UniProt: Q9BVV7

  • Chr Location
    18q22.3; chr18:74148523-74160531 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    79
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024645 Ensembl Gene Model | MGI Sequence Detail 5334 C57BL/6J ±  kb
    transcript ENSMUST00000025547 Ensembl | MGI Sequence Detail 2418 Not Applicable  
    polypeptide ENSMUSP00000025547 Ensembl | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000030615 mitochondrial import inner membrane translocase subunit Tim21
      (term hierarchy)
    • InterPro Domains
      IPR013261 Mitochondrial import inner membrane translocase subunit Tim21
      IPR038552 Tim21 IMS domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 79
      cDNA 79

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1914355
    References
    more
    • Summaries
      All 36
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/20/2026
    MGI 6.24     		The Jackson Laboratory