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Itpripl1 Gene Detail
Summary
  • Symbol
    Itpripl1
  • Name
    inositol 1,4,5-triphosphate receptor interacting protein-like 1
  • Synonyms
    1700041B20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920588
    NCBI Gene: 73338
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:126980692-126985362 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 61.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920588
 protein coding gene Chr2:126980689-126985377 (-)
129S1/SvImJ ENSMUSG00200044718
 protein coding gene Chr2:124033606-124038276 (-)
A/J ENSMUSG00195028691
 protein coding gene Chr2:124062333-124067005 (-)
AKR/J ENSMUSG00220039232
 protein coding gene Chr2:123819878-123824550 (-)
BALB/cJ ENSMUSG00180047888
 protein coding gene Chr2:123849233-123853905 (-)
C3H/HeJ ENSMUSG00175039515
 protein coding gene Chr2:124391983-124396643 (-)
C57BL/6NJ ENSMUSG00215021220
 protein coding gene Chr2:123901963-123906633 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024248
 protein coding gene Chr2:119817411-119822061 (-)
CAST/EiJ ENSTCUG00005039862
 protein coding gene Chr2:123189144-123193824 (-)
CBA/J ENSMUSG00210032031
 protein coding gene Chr2:124242473-124247133 (-)
DBA/2J ENSMUSG00185035222
 protein coding gene Chr2:123896420-123901080 (-)
FVB/NJ ENSMUSG00205032233
 protein coding gene Chr2:123056703-123061373 (-)
JF1/MsJ ENSUMUG00000011859
 protein coding gene Chr2:123746622-123751282 (-)
LP/J ENSMUSG00230036504
 protein coding gene Chr2:125669045-125673716 (-)
NOD/ShiLtJ ENSMUSG00190015119
 protein coding gene Chr2:124026842-124031513 (-)
NZO/HlLtJ ENSMUSG00225026662
 protein coding gene Chr2:133575222-133579893 (-)
PWK/PhJ ENSLUMG00010039706
 protein coding gene Chr2:123632485-123637137 (-)
SPRET/EiJ ENSMSPG00010030169
 protein coding gene Chr2:126064907-126068298 (-)
WSB/EiJ ENSIUOG00005036669
 protein coding gene Chr2:123830190-123834866 (-)



Homology
more
  • Human Ortholog
    ITPRIPL1, ITPRIP like 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITPRIPL1, ITPRIP like 1
  • Synonyms
    D1B, KIAA1754L
  • Links
    NCBI Gene ID: 150771
    UniProt: Q6GPH6

  • Chr Location
    2q11.2; chr2:96324977-96330517 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show impaired sperm motility, an increase in T cell infiltration within the testis and moderate shrinkage in certain tissue regions of the testis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074825 Ensembl Gene Model | MGI Sequence Detail 4671 C57BL/6J ±  kb
    transcript ENSMUST00000154021 Ensembl | MGI Sequence Detail 1753 Not Applicable  
    polypeptide ENSMUSP00000122289 Ensembl | MGI Sequence Detail 547 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000009162 inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
      (term hierarchy)
    • InterPro Domains
      IPR026250 Inositol 1,4,5-trisphosphate receptor-interacting protein-like
      IPR024810 MAB21L/Cyclic GMP-AMP synthase-like receptor
      IPR046906 Mab-21-like, HhH/H2TH-like domain
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 2
      cDNA 14

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:348064 Deng S, et al., ITPRIPL1 binds CD3epsilon to impede T cell activation and enable tumor immune evasion. Cell. 2024 Apr 25;187(9):2305-2323.e33
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory