Gpbp1 MGI Mouse Gene Detail - MGI:1920524 - GC-rich promoter binding protein 1

Symbol

Gpbp1
Name

GC-rich promoter binding protein 1
Synonyms

1700034P14Rik, D230035M11Rik

Feature Type

protein coding gene
IDs

MGI:1920524
NCBI Gene: 73274
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr13:111562214-111626645 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.23 cM, cytoband D2.1
Mapping Data

3 experiments

SNPs within 2kb

325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920524	protein coding gene	Chr13:111562214-111626658 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020932	protein coding gene	Chr13:113924465-113999345 (-)
A/J	MGP_AJ_G0020882	protein coding gene	Chr13:109388746-109455267 (-)
AKR/J	MGP_AKRJ_G0020857	protein coding gene	Chr13:112686713-112754899 (-)
BALB/cJ	MGP_BALBcJ_G0020882	protein coding gene	Chr13:110089139-110156968 (-)
C3H/HeJ	MGP_C3HHeJ_G0020671	protein coding gene	Chr13:112470445-112539344 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021317	protein coding gene	Chr13:117296483-117376830 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018886	protein coding gene	Chr13:104716481-104783798 (-)
CAST/EiJ	MGP_CASTEiJ_G0020190	protein coding gene	Chr13:112083703-112156843 (-)
CBA/J	MGP_CBAJ_G0020633	protein coding gene	Chr13:121822911-121897214 (-)
DBA/2J	MGP_DBA2J_G0020756	protein coding gene	Chr13:109108937-109174593 (-)
FVB/NJ	MGP_FVBNJ_G0020739	protein coding gene	Chr13:107792324-107866074 (-)
LP/J	MGP_LPJ_G0020831	protein coding gene	Chr13:113963252-114036674 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020767	protein coding gene	Chr13:122184752-122261386 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021355	protein coding gene	Chr13:112140592-112207691 (-)
PWK/PhJ	MGP_PWKPhJ_G0019943	protein coding gene	Chr13:107839086-107904933 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019765	protein coding gene	Chr13:108449736-108516320 (-)
WSB/EiJ	MGP_WSBEiJ_G0020248	protein coding gene	Chr13:112725580-112793026 (-)

Human Ortholog

GPBP1, GC-rich promoter binding protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPBP1, GC-rich promoter binding protein 1
Synonyms

GPBP, SSH6, VASCULIN
Links

HGNC:29520

NCBI Gene ID: 65056

neXtProt AC: NX_Q86WP2

UniProt: Q86WP2
Chr Location

5q11.2; chr5:57173948-57264679 (+) GRCh38

MGI Vertebrate Homology

Gpbp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GPBP1
Gene Tree

Gpbp1

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Gene trapped

20
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

73 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

20

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpbp1

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All Sequences

80
RefSeq

22
UniProt

3
CCDS

CCDS26769.1, CCDS49362.1

Ensembl

ENSMUSG00000032745 (Evidence)
NCBI Gene

73274

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032745	Ensembl Gene Model \| MGI Sequence Detail	64432	C57BL/6J	± kb
transcript	ENSMUST00000047627	Ensembl \| MGI Sequence Detail	3694	Not Applicable
polypeptide	ENSMUSP00000048240	Ensembl \| MGI Sequence Detail	493	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008161 vasculin

(term hierarchy)
InterPro Domains

IPR028128 Vasculin family

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All nucleic 23

cDNA 23

Microarray probesets 5

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MGI:2145353, MGI:2443761

Summaries

All 34

Gene Ontology 5

Phenotypes 8
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Gpbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr124029	Chr13:111626655-111626673 (-)	-19 bp
Tssr124028	Chr13:111626589-111626634 (-)	33 bp
Tssr124027	Chr13:111626503-111626512 (-)	137 bp
Tssr124026	Chr13:111626431-111626453 (-)	203 bp
Tssr124025	Chr13:111626369-111626424 (-)	248 bp
Tssr124024	Chr13:111626307-111626327 (-)	328 bp
Tssr124023	Chr13:111626303-111626306 (-)	340 bp
Tssr124022	Chr13:111618855-111618868 (-)	7,783 bp
Tssr124021	Chr13:111585757-111585806 (-)	40,863 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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