Cib4 Gene Detail

Summary

• Symbol
  Cib4
• Name
  calcium and integrin binding family member 4
• Synonyms
  1700041E20Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1920509
  NCBI Gene: 73259
• Alliance
  genome feature page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr5:30642927-30703180 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 16.59 cM, cytoband B1
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  1648 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920509	protein coding gene	Chr5:30642927-30703191 (-)
129S1/SvImJ	ENSMUSG00200012930	protein coding gene	Chr5:26143474-26203213 (-)
A/J	ENSMUSG00195045986	protein coding gene	Chr5:25591175-25651419 (-)
AKR/J	ENSMUSG00220008131	protein coding gene	Chr5:25604640-25664380 (-)
BALB/cJ	ENSMUSG00180028692	protein coding gene	Chr5:25395786-25456026 (-)
C3H/HeJ	ENSMUSG00175043588	protein coding gene	Chr5:27370128-27430372 (-)
C57BL/6NJ	ENSMUSG00215039617	protein coding gene	Chr5:26105795-26166050 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027059	protein coding gene	Chr5:24989546-25051118 (-)
CAST/EiJ	ENSTCUG00005019011	protein coding gene	Chr5:25576897-25639859 (-)
CBA/J	ENSMUSG00210042470	protein coding gene	Chr5:26343299-26403545 (-)
DBA/2J	ENSMUSG00185033571	protein coding gene	Chr5:28197053-28257303 (-)
FVB/NJ	ENSMUSG00205023074	protein coding gene	Chr5:25094705-25154957 (-)
JF1/MsJ	ENSUMUG00000036126	protein coding gene	Chr5:32741876-32803572 (-)
LP/J	ENSMUSG00230043487	protein coding gene	Chr5:32813926-32873662 (-)
NOD/ShiLtJ	ENSMUSG00190011789	protein coding gene	Chr5:25394119-25454369 (-)
NZO/HlLtJ	ENSMUSG00225020057	protein coding gene	Chr5:38021610-38081859 (-)
PWK/PhJ	ENSLUMG00010038430	protein coding gene	Chr5:25492483-25554233 (-)
SPRET/EiJ	ENSMSPG00010042388	protein coding gene	Chr5:26609465-26672819 (-)
WSB/EiJ	ENSIUOG00005036906	protein coding gene	Chr5:28294643-28354131 (-)

Homology

• Human Ortholog
  CIB4, calcium and integrin binding family member 4

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CIB4, calcium and integrin binding family member 4
  
• Synonyms
  KIP4
• Links
  HGNC:33703

  NCBI Gene ID: 130106

  UniProt: A0PJX0

  
  
• Chr Location
  2p23.3; chr2:26581205-26641366 (-)  GRCh38

---

• MGI Vertebrate Homology
  Cib4 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: CIB4
• Gene Tree
  Cib4
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 2 alleles in 2 genetic backgrounds
  29 phenotype references
  

• All Mutations and Alleles
  15
• Chemically induced (other)
  2
• Endonuclease-mediated
  7
• Gene trapped
  1
• Radiation induced
  3
• Spontaneous
  1
• Targeted
  1
• Genomic Mutations
  6 involving Cib4
• Find Mice (IMSR)
  13 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Male mice homozygous for a null allele exhibit infertility with impaired spermatogenesis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  10
• GO References
  6

Expression

• Assay Results
  603
• Tissues
  2
• cDNA Data
  5
• Literature Summary
  1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  33
• RefSeq
  6
• UniProt
  1
• CCDS
  CCDS51453.1

• Ensembl
  ENSMUSG00000053194 (Evidence)
• NCBI Gene
  73259

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000053194	Ensembl Gene Model | MGI Sequence Detail	60254	C57BL/6J
transcript	ENSMUST00000065486	Ensembl | MGI Sequence Detail	769	Not Applicable
polypeptide	ENSMUSP00000066222	Ensembl | MGI Sequence Detail	185	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000031838 calcium and integrin-binding family member 4
  (term hierarchy)
• InterPro Domains
  IPR051433 Calcium and Integrin-Binding
  IPR018247 EF-Hand 1, calcium-binding site
  IPR002048 EF-hand domain
  IPR011992 EF-hand domain pair

Molecular
Reagents

• All nucleic 6

  cDNA 5

  Primer pair 1

  
  

  Microarray probesets 2

References

• Summaries
  All 52

  Developmental Gene Expression 1

  Diseases 1

  Gene Ontology 6

  Phenotypes 29
• Earliest
  J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cib4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50494	Chr5:30703180-30703196 (-)	-8 bp
Tssr50493	Chr5:30703154-30703166 (-)	20 bp