Mrgbp MGI Mouse Gene Detail - MGI:1920497 - MRG/MORF4L binding protein

Symbol

Mrgbp
Name

MRG/MORF4L binding protein
Synonyms

1600027N09Rik

Feature Type

protein coding gene
IDs

MGI:1920497
NCBI Gene: 73247
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:180223097-180228097 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 103.12 cM
Mapping Data

2 experiments

SNPs within 2kb

54 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920497	protein coding gene	Chr2:180222990-180228097 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026996	protein coding gene	Chr2:187111794-187116794 (+)
A/J	MGP_AJ_G0026962	protein coding gene	Chr2:179424321-179429322 (+)
AKR/J	MGP_AKRJ_G0026932	protein coding gene	Chr2:184803496-184808497 (+)
BALB/cJ	MGP_BALBcJ_G0026971	protein coding gene	Chr2:179887001-179892016 (+)
C3H/HeJ	MGP_C3HHeJ_G0026712	protein coding gene	Chr2:185153488-185158489 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027417	protein coding gene	Chr2:192513221-192518221 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024782	protein coding gene	Chr2:170116210-170121209 (+)
CAST/EiJ	MGP_CASTEiJ_G0026171	protein coding gene	Chr2:183394250-183401203 (+)
CBA/J	MGP_CBAJ_G0026689	protein coding gene	Chr2:199512238-199517238 (+)
DBA/2J	MGP_DBA2J_G0026827	protein coding gene	Chr2:178521631-178526632 (+)
FVB/NJ	MGP_FVBNJ_G0026793	protein coding gene	Chr2:177136456-177141448 (+)
LP/J	MGP_LPJ_G0026928	protein coding gene	Chr2:187117901-187122901 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026812	protein coding gene	Chr2:202113748-202118748 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027476	protein coding gene	Chr2:184759578-184764579 (+)
PWK/PhJ	MGP_PWKPhJ_G0025907	protein coding gene	Chr2:176033062-176038102 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025707	protein coding gene	Chr2:181251752-181256504 (+)
WSB/EiJ	MGP_WSBEiJ_G0026243	protein coding gene	Chr2:185740953-185745993 (+)

Human Ortholog

MRGBP, MRG domain binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRGBP, MRG domain binding protein
Synonyms

C20orf20, Eaf7, MRG15BP, URCC4
Links

HGNC:15866

NCBI Gene ID: 55257

neXtProt AC: NX_Q9NV56

UniProt: Q9NV56
Chr Location

20q13.33; chr20:62796405-62801738 (+) GRCh38.p7

Alliance of Genome Resources

Mrgbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRGBP
Gene Tree

Mrgbp

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

APF
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

48

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrgbp

ZFIN mrgbp

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Mrgbp interacts with 158 markers (Mir10a, Mir15a, Mir16-1, ...) View All

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All Sequences

52
RefSeq

8
UniProt

2
CCDS

CCDS17178.1

Ensembl

ENSMUSG00000027569 (Evidence)
NCBI Gene

73247

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027569	Ensembl Gene Model \| MGI Sequence Detail	5001	C57BL/6J	± kb
transcript	ENSMUST00000169630	Ensembl \| MGI Sequence Detail	1192	Not Applicable
polypeptide	ENSMUSP00000127747	Ensembl \| MGI Sequence Detail	204	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010564 MRG/MORF4L-binding protein

(term hierarchy)
InterPro Domains

IPR012423 Chromatin modification-related protein Eaf7/MRGBP

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All nucleic 50

cDNA 50

Microarray probesets 4

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MGI:2139286, MGI:2139504

Summaries

All 32

Gene Ontology 6

Phenotypes 3
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:319957 Jacquet K, et al., The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Mol Cell. 2016 May 5;62(3):409-421

TSS for Mrgbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22248	Chr2:180222992-180223012 (+)	-95 bp
Tssr22249	Chr2:180223013-180223036 (+)	-72 bp
Tssr22250	Chr2:180224519-180224535 (+)	1,430 bp
Tssr22251	Chr2:180224543-180224570 (+)	1,460 bp
Tssr22252	Chr2:180224573-180224591 (+)	1,485 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 05/24/2023 MGI 6.22