Nfatc4 MGI Mouse Gene Detail - MGI:1920431 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

Symbol

Nfatc4
Name

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Synonyms

3110041H08Rik

Feature Type

protein coding gene
IDs

MGI:1920431
NCBI Gene: 73181
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:56062252-56071400 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

255 from dbSNP Build 142
Strain Annotations

24

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920431	protein coding gene	Chr14:56060601-56071400 (+)
129S1/SvImJ	ENSMUSG00200040943	protein coding gene	Chr14:44651336-44658817 (+)
129S1/SvImJ	ENSMUSGG00200054563	protein coding gene	Chr14:44650186-44651410 (+)
A/J	ENSMUSGG00195055081	protein coding gene	Chr14:44866933-44868157 (+)
A/J	ENSMUSG00195027643	protein coding gene	Chr14:44868083-44875559 (+)
AKR/J	ENSMUSG00220023764	protein coding gene	Chr14:44195962-44203440 (+)
AKR/J	ENSMUSGG00220054458	protein coding gene	Chr14:44194813-44196036 (+)
BALB/cJ	ENSMUSG00180050274	protein coding gene	Chr14:44491794-44499267 (+)
BALB/cJ	ENSMUSGG00180055137	protein coding gene	Chr14:44490645-44491868 (+)
C3H/HeJ	ENSMUSG00175042566	protein coding gene	Chr14:46174126-46181601 (+)
C3H/HeJ	ENSMUSGG00175054638	protein coding gene	Chr14:46172976-46174200 (+)
C57BL/6NJ	ENSMUSG00215047584	protein coding gene	Chr14:44386877-44394355 (+)
C57BL/6NJ	ENSMUSGG00215055379	protein coding gene	Chr14:44385728-44386951 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019321	protein coding gene	Chr14:47234858-47243940 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210054697	protein coding gene	Chr14:44853524-44854748 (+)
CBA/J	ENSMUSG00210042672	protein coding gene	Chr14:44854674-44862151 (+)
DBA/2J	ENSMUSGG00185057424	protein coding gene	Chr14:49913113-49914339 (+)
FVB/NJ	ENSMUSGG00205054203	protein coding gene	Chr14:44256439-44257663 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230052103	protein coding gene	Chr14:62017191-62024667 (+)
LP/J	ENSMUSGG00230055319	protein coding gene	Chr14:62016041-62017265 (+)
NOD/ShiLtJ	ENSMUSGG00190054635	protein coding gene	Chr14:44619813-44621037 (+)
NZO/HlLtJ	ENSMUSGG00225055302	protein coding gene	Chr14:52306410-52307634 (+)
NZO/HlLtJ	ENSMUSG00225046017	protein coding gene	Chr14:52307560-52315040 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010045703	protein coding gene	Chr14:47464302-47473388 (+)
WSB/EiJ	no annotation

Human Ortholog

NFATC4, nuclear factor of activated T cells 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFATC4, nuclear factor of activated T cells 4
Synonyms

NF-AT3, NFAT3, NF-ATC4
Links

HGNC:7778

NCBI Gene ID: 4776

UniProt: Q14934
Chr Location

14q12; chr14:24365673-24379604 (+) GRCh38

MGI Vertebrate Homology

Nfatc4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NFATC4
Gene Tree

Nfatc4

Diseases

1 with human NFATC4 associations

				Human Disease	Mouse Models
				dilated cardiomyopathy IDs dilated cardiomyopathy DOID:12930 EFO:0000407 ICD10CM:I42.0 KEGG:05414 MESH:D002311 NCI:C84673 OMIM:PS115200 ORDO:217604 UMLS_CUI:C0007193

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
39 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Nfatc4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and overtly normal and exhibit normal embryonic heart morphology as well as normal pathophysiologic cardiac hypertrophy in response to angiotensin II infusion or aortic banding.

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All GO Annotations

79
GO References

26

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

130
cDNA Data

48
Literature Summary

31

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nfatc4

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All Sequences

70
RefSeq

4
UniProt

6
CCDS

CCDS27132.1, CCDS49500.1

Ensembl

ENSMUSG00000023411 (Evidence)
NCBI Gene

73181

			Length	Strain/Species	Flank
genomic	73181	NCBI Gene Model \| MGI Sequence Detail	9149	C57BL/6J	± kb
transcript	NM_001168346	RefSeq \| MGI Sequence Detail	4036	C57BL/6
polypeptide	Q8K120	UniProt \| EBI \| MGI Sequence Detail	901	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000011167 nuclear factor of activated T-cells, cytoplasmic 4

(term hierarchy)
InterPro Domains

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR008366 Nuclear factor of activated T cells (NFAT)

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR032397 Rel homology dimerisation domain

IPR011539 Rel homology domain, DNA-binding domain

IPR037059 Rel homology domain (RHD), DNA-binding domain superfamily
GlyGen

Q8K120 3 sites

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All nucleic 53

cDNA 48

Primer pair 4

Other 1

Microarray probesets 5

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MGI:2145795, MGI:2145827

Summaries

All 119

Developmental Gene Expression 31

Diseases 1

Gene Ontology 26

Phenotypes 26
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nfatc4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125820	Chr14:56062318-56062346 (+)	80 bp
Tssr125821	Chr14:56062362-56062376 (+)	117 bp
Tssr125822	Chr14:56062401-56062420 (+)	159 bp
Tssr125823	Chr14:56062426-56062468 (+)	195 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24