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Tbkbp1 Gene Detail
Summary
  • Symbol
    Tbkbp1
  • Name
    TBK1 binding protein 1
  • Synonyms
    3110043L15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920424
    NCBI Gene: 73174
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97026997-97042321 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    438 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920424
 protein coding gene Chr11:97026997-97042332 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019025
 protein coding gene Chr11:99522087-99536950 (-)
A/J MGP_AJ_G0018993
 protein coding gene Chr11:95446897-95462215 (-)
AKR/J MGP_AKRJ_G0018963
 protein coding gene Chr11:98411610-98426875 (-)
BALB/cJ MGP_BALBcJ_G0018966
 protein coding gene Chr11:95934818-95949682 (-)
C3H/HeJ MGP_C3HHeJ_G0018780
 protein coding gene Chr11:98520109-98536412 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019418
 protein coding gene Chr11:102611918-102626777 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017049
 protein coding gene Chr11:92907952-92923370 (-)
CAST/EiJ MGP_CASTEiJ_G0018333
 protein coding gene Chr11:99372193-99387128 (-)
CBA/J MGP_CBAJ_G0018751
 protein coding gene Chr11:106837877-106852739 (-)
DBA/2J MGP_DBA2J_G0018859
 protein coding gene Chr11:94997486-95012350 (-)
FVB/NJ MGP_FVBNJ_G0018848
 protein coding gene Chr11:94479776-94495435 (-)
LP/J MGP_LPJ_G0018929
 protein coding gene Chr11:100052732-100067595 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018875
 protein coding gene Chr11:106737001-106751917 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019458
 protein coding gene Chr11:98701058-98715926 (-)
PWK/PhJ MGP_PWKPhJ_G0018105
 protein coding gene Chr11:95971434-95986489 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017895
 protein coding gene Chr11:98415266-98431696 (-)
WSB/EiJ MGP_WSBEiJ_G0018383
 protein coding gene Chr11:98609102-98625384 (-)



Homology
more
  • Human Ortholog
    TBKBP1, TBK1 binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBKBP1, TBK1 binding protein 1
  • Synonyms
    ProSAPiP2, SINTBAD
  • Links
    NCBI Gene ID: 9755
    UniProt: A7MCY6

  • Chr Location
    17q21.32; chr17:47694063-47712063 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal GM-CSF-derived bone marrow-derived dendritic cell differentiation and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    15
  • cDNA Data
    28
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038517 Ensembl Gene Model | MGI Sequence Detail 15325 C57BL/6J ±  kb
transcript ENSMUST00000107614 Ensembl | MGI Sequence Detail 2391 Not Applicable  
polypeptide ENSMUSP00000103239 Ensembl | MGI Sequence Detail 611 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 17
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory