Trmt10a MGI Mouse Gene Detail - MGI:1920421 - tRNA methyltransferase 10A

Symbol

Trmt10a
Name

tRNA methyltransferase 10A
Synonyms

3110023L08Rik, Rg9mtd2

Feature Type

protein coding gene
IDs

MGI:1920421
NCBI Gene: 108943
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:137849214-137865582 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 64.09 cM
Mapping Data

2 experiments

SNPs within 2kb

539 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920421	protein coding gene	Chr3:137849209-137865582 (+)
129S1/SvImJ	ENSMUSG00200002954	protein coding gene	Chr3:134640691-134657124 (+)
A/J	ENSMUSG00195004196	protein coding gene	Chr3:134749074-134765495 (+)
AKR/J	ENSMUSG00220002977	protein coding gene	Chr3:133199660-133216089 (+)
BALB/cJ	ENSMUSG00180011253	protein coding gene	Chr3:134663171-134679597 (+)
C3H/HeJ	ENSMUSG00175018655	protein coding gene	Chr3:134266516-134282938 (+)
C57BL/6NJ	ENSMUSG00215018370	protein coding gene	Chr3:135008252-135024630 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025676	protein coding gene	Chr3:131612063-131628076 (+)
CAST/EiJ	ENSTCUG00005028657	protein coding gene	Chr3:135354652-135371212 (+)
CBA/J	ENSMUSG00210031014	protein coding gene	Chr3:134876350-134892771 (+)
DBA/2J	ENSMUSG00185003311	protein coding gene	Chr3:135493527-135509956 (+)
FVB/NJ	ENSMUSG00205016587	protein coding gene	Chr3:133801187-133817620 (+)
JF1/MsJ	ENSUMUG00000004312	protein coding gene	Chr3:134257854-134274395 (+)
LP/J	ENSMUSG00230002449	protein coding gene	Chr3:137454424-137470857 (+)
NOD/ShiLtJ	ENSMUSG00190004369	protein coding gene	Chr3:135874809-135891238 (+)
NZO/HlLtJ	ENSMUSG00225004512	protein coding gene	Chr3:139922413-139938846 (+)
PWK/PhJ	ENSLUMG00010020319	protein coding gene	Chr3:134174997-134190200 (+)
SPRET/EiJ	ENSMSPG00010014048	protein coding gene	Chr3:135347360-135363821 (+)
WSB/EiJ	ENSIUOG00005017728	protein coding gene	Chr3:135035039-135051448 (+)

Human Ortholog

TRMT10A, tRNA methyltransferase 10A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRMT10A, tRNA methyltransferase 10A
Synonyms

HEL-S-88, MSSGM, MSSGM1, RG9MTD2, TRM10
Links

HGNC:28403

NCBI Gene ID: 93587

UniProt: Q8TBZ6
Chr Location

4q23; chr4:99546709-99564039 (-) GRCh38

MGI Vertebrate Homology

Trmt10a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRMT10A
Protein SuperFamily

tRNA_m1G_mtfrase_met
Gene Tree

Trmt10a

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References

1 with disease annotations

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Phenotype Summary

22 phenotypes from 2 alleles in 3 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

134
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

126
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Trmt10a
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit decreased body and brain weight, smaller hippocampal postsynaptic densities, defective synaptic plasticity and spatial learning and memory, and reduced motor coordination. Another knock-out shows increased magnesium level.

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All GO Annotations

25
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

666
Tissues

13
cDNA Data

14
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trmt10a

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All Sequences

98
RefSeq

44
UniProt

6
CCDS

CCDS17866.1

Ensembl

ENSMUSG00000004127 (Evidence)
NCBI Gene

108943

			Length	Strain/Species	Flank
genomic	108943	NCBI Gene Model \| MGI Sequence Detail	16369	C57BL/6J	± kb
transcript	NM_001404369	RefSeq \| MGI Sequence Detail	4418	C57BL/6
polypeptide	Q8C1Z8	UniProt \| EBI \| MGI Sequence Detail	328	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013933 tRNA methyltransferase 10 homolog A

(term hierarchy)
EC

2.1.1.221
InterPro Domains

IPR007356 tRNA (guanine(9)-N1)-methyltransferase, eukaryotic

IPR016653 tRNA (guanine(9)-N(1))-methyltransferase TRM10/TRM10A

IPR028564 tRNA methyltransferase TRM10-type domain

IPR038459 tRNA methyltransferase TRM10-type domain superfamily

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All nucleic 14

cDNA 14

Microarray probesets 6

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MGI:3034323

Summaries

All 47

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:358937 Tresky R, et al., TRMT10A dysfunction perturbs codon translation of initiator methionine and glutamine and impairs brain functions in mice. Nucleic Acids Res. 2024 Aug 27;52(15):9230-9246

TSS for Trmt10a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31944	Chr3:137849190-137849238 (+)	0 bp
Tssr31945	Chr3:137849244-137849257 (+)	37 bp
Tssr31946	Chr3:137849583-137849604 (+)	380 bp
Tssr31947	Chr3:137849607-137849647 (+)	413 bp
Tssr31948	Chr3:137849649-137849680 (+)	451 bp
Tssr31949	Chr3:137849683-137849698 (+)	477 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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