Prss57 MGI Mouse Gene Detail - MGI:1920356

Symbol

Prss57
Name

serine protease 57
Synonyms

2900092M14Rik, GLGL782, Prssl1, UNQ782

Feature Type

protein coding gene
IDs

MGI:1920356
NCBI Gene: 73106
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr10:79617308-79626795 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

1 experiment

SNPs within 2kb

11 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920356	protein coding gene	Chr10:79617308-79630523 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017460	protein coding gene	Chr10:80325168-80334651 (-)
A/J	MGP_AJ_G0017438	protein coding gene	Chr10:77534853-77544203 (-)
AKR/J	MGP_AKRJ_G0017399	protein coding gene	Chr10:79642322-79651592 (-)
BALB/cJ	MGP_BALBcJ_G0017400	protein coding gene	Chr10:77761010-77770455 (-)
C3H/HeJ	MGP_C3HHeJ_G0017223	protein coding gene	Chr10:79751312-79761071 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017854	protein coding gene	Chr10:83100386-83109865 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015542	protein coding gene	Chr10:73760442-73770498 (-)
CAST/EiJ	MGP_CASTEiJ_G0016790	protein coding gene	Chr10:79924204-79940955 (-)
CBA/J	MGP_CBAJ_G0017195	protein coding gene	Chr10:86325295-86334771 (-)
DBA/2J	MGP_DBA2J_G0017301	protein coding gene	Chr10:76749914-76759402 (-)
FVB/NJ	MGP_FVBNJ_G0017295	protein coding gene	Chr10:75921246-75932136 (-)
LP/J	MGP_LPJ_G0017372	protein coding gene	Chr10:80808908-80819733 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017321	protein coding gene	Chr10:88306952-88315970 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017895	protein coding gene	Chr10:79621705-79631168 (-)
PWK/PhJ	MGP_PWKPhJ_G0016571	protein coding gene	Chr10:76609019-76619386 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016360	protein coding gene	Chr10:78599890-78611426 (-)
WSB/EiJ	MGP_WSBEiJ_G0016850	protein coding gene	Chr10:79651634-79661142 (-)

Human Ortholog

PRSS57, serine protease 57

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRSS57, serine protease 57
Synonyms

NSP4, PRSSL1, UNQ782
Links

HGNC:31397

NCBI Gene ID: 400668

neXtProt AC: NX_Q6UWY2

UniProt: Q6UWY2
Chr Location

19p13.3; chr19:685546-695498 (-) GRCh38

MGI Vertebrate Homology

Prss57 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PRSS57
Gene Tree

Prss57

less

Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

5
Genomic Mutations

1 involving Prss57
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display reduced levels of histamine and serotonin in mast cells resulting in defects in mast cell function.

less

All GO Annotations

11
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

50
RefSeq

15
UniProt

3
CCDS

CCDS35968.1

Ensembl

ENSMUSG00000020323 (Evidence)
NCBI Gene

73106

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020323	Ensembl Gene Model \| MGI Sequence Detail	9488	C57BL/6J	± kb
transcript	ENSMUST00000169684	Ensembl \| MGI Sequence Detail	2841	Not Applicable
polypeptide	ENSMUSP00000132215	Ensembl \| MGI Sequence Detail	284	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000013331 serine protease 57

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

less

All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 35

Gene Ontology 3

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:301479 AhYoung AP, et al., Neutrophil serine protease 4 is required for mast cell-dependent vascular leakage. Commun Biol. 2020 Nov 19;3(1):687

TSS for Prss57:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98351	Chr10:79624758-79624818 (-)	2,007 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23