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Wdr11 Gene Detail
Summary
  • Symbol
    Wdr11
  • Name
    WD repeat domain 11
  • Synonyms
    2900055P10Rik, Brwd2, MGC:47139, Wdr11
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920230
    NCBI Gene: 207425
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:129193587-129237462 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 72.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    593 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920230
 protein coding gene Chr7:129193373-129237462 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033089
 protein coding gene Chr7:134071144-134119048 (+)
A/J MGP_AJ_G0033071
 protein coding gene Chr7:130427984-130471346 (+)
AKR/J MGP_AKRJ_G0033003
 protein coding gene Chr7:133885920-133929292 (+)
BALB/cJ MGP_BALBcJ_G0033072
 protein coding gene Chr7:130101400-130145215 (+)
C3H/HeJ MGP_C3HHeJ_G0032786
 protein coding gene Chr7:133764695-133808724 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033582
 protein coding gene Chr7:139255897-139299137 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030554
 protein coding gene Chr7:131605629-131651007 (+)
CAST/EiJ MGP_CASTEiJ_G0032116
 protein coding gene Chr7:125565807-125616016 (+)
CBA/J MGP_CBAJ_G0032759
 protein coding gene Chr7:144011769-144058073 (+)
DBA/2J MGP_DBA2J_G0032911
 protein coding gene Chr7:128427007-128470293 (+)
FVB/NJ MGP_FVBNJ_G0032864
 protein coding gene Chr7:128288535-128332255 (+)
LP/J MGP_LPJ_G0033005
 protein coding gene Chr7:135548511-135595737 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032896
 protein coding gene Chr7:145041580-145086189 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033601
 protein coding gene Chr7:132825293-132869785 (+)
PWK/PhJ MGP_PWKPhJ_G0031822
 protein coding gene Chr7:121462016-121509368 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031668
 protein coding gene Chr7:119655929-119707045 (+)
WSB/EiJ MGP_WSBEiJ_G0032227
 protein coding gene Chr7:133817073-133861305 (+)



Homology
more
  • Human Ortholog
    WDR11, WD repeat domain 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR11, WD repeat domain 11
  • Synonyms
    BRWD2, DR11, HH14, SRI1, WDR15
  • Links
    NCBI Gene ID: 55717
    neXtProt AC: NX_Q9BZH6
    UniProt: Q9BZH6

  • Chr Location
    10q26.12; chr10:120851305-120909524 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Wdr11 mouse models; 2 with human WDR11 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    91 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show mid-gestational and perinatal lethality and developmental anomalies associated with defective Hh signalling and ciliogenesis, including eye, skeletal, heart and craniofacial defects, holoprosencephaly, pituitary dysgenesis, delayed puberty, reproductive dysfunction and obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    756
  • Tissues
    29
  • cDNA Data
    78
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042055 Ensembl Gene Model | MGI Sequence Detail 43876 C57BL/6J ±  kb
    transcript ENSMUST00000084519 Ensembl | MGI Sequence Detail 4550 Not Applicable  
    polypeptide ENSMUSP00000081567 Ensembl | MGI Sequence Detail 1223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 78
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2142234
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:338829 Lee J, et al., Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development. Sci Rep. 2023 Jul 29;13(1):12309
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory