Macrod2 MGI Mouse Gene Detail - MGI:1920149 - mono-ADP ribosylhydrolase 2

Symbol

Macrod2
Name

mono-ADP ribosylhydrolase 2
Synonyms

1110033L15Rik, 2610107G07Rik, 2900006F19Rik

Feature Type

protein coding gene
IDs

MGI:1920149
NCBI Gene: 72899
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr2:140237229-142234886 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 69.20 cM, cytoband G3
Mapping Data

2 experiments

SNPs within 2kb

83044 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920149	protein coding gene	Chr2:140237223-142234886 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026571	protein coding gene	Chr2:144328694-146378984 (+)
A/J	MGP_AJ_G0026535	protein coding gene	Chr2:138492790-140451088 (+)
AKR/J	MGP_AKRJ_G0026509	protein coding gene	Chr2:142455405-144495574 (+)
BALB/cJ	MGP_BALBcJ_G0026547	protein coding gene	Chr2:138897337-140895955 (+)
C3H/HeJ	MGP_C3HHeJ_G0026290	protein coding gene	Chr2:142978509-145044148 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026992	protein coding gene	Chr2:148675128-150800202 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024368	protein coding gene	Chr2:132805552-134741221 (+)
CAST/EiJ	MGP_CASTEiJ_G0025751	protein coding gene	Chr2:143290453-145394892 (+)
CBA/J	MGP_CBAJ_G0026270	protein coding gene	Chr2:154104491-156302829 (+)
DBA/2J	MGP_DBA2J_G0026404	protein coding gene	Chr2:137824293-139793797 (+)
FVB/NJ	MGP_FVBNJ_G0026368	protein coding gene	Chr2:136384301-138346463 (+)
LP/J	MGP_LPJ_G0026508	protein coding gene	Chr2:144470720-146564137 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026388	protein coding gene	Chr2:158141115-160529999 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027047	protein coding gene	Chr2:142433865-144518089 (+)
PWK/PhJ	MGP_PWKPhJ_G0025487	protein coding gene	Chr2:137407043-139429899 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025288	protein coding gene	Chr2:141506405-143570800 (+)
WSB/EiJ	MGP_WSBEiJ_G0025824	protein coding gene	Chr2:143426431-145504732 (+)

Human Ortholog

MACROD2, mono-ADP ribosylhydrolase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MACROD2, mono-ADP ribosylhydrolase 2
Synonyms

C20orf133, C2orf133
Links

HGNC:16126

NCBI Gene ID: 140733

UniProt: A1Z1Q3
Chr Location

20p12.1; chr20:13995369-16053197 (+) GRCh38

MGI Vertebrate Homology

Macrod2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: MACROD2
Gene Tree

Macrod2

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

2
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Macrod2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable, healthy and overtly normal and show no significant changes in irradiation-induced lethality, high fat diet-induced obesity, or response to glucose or insulin challenge relative to wild-type controls.

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All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

899
Tissues

150
cDNA Data

35
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase macrod2

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All Sequences

113
RefSeq

48
UniProt

9
CCDS

CCDS16805.1, CCDS50733.1

Ensembl

ENSMUSG00000068205 (Evidence)
NCBI Gene

72899

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068205	Ensembl Gene Model \| MGI Sequence Detail	1997658	C57BL/6J	± kb
transcript	ENSMUST00000110064	Ensembl \| MGI Sequence Detail	4883	Not Applicable
polypeptide	ENSMUSP00000105691	Ensembl \| MGI Sequence Detail	475	Not Applicable

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UniProt

9 Sequences
EC

3.2.2.-, 3.5.1.-
InterPro Domains

IPR002589 Macro domain

IPR043472 Macro domain-like
GlyGen

Q3UYG8 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 37

cDNA 35

Primer pair 2

Microarray probesets 12

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MGI:1917687, MGI:1921002

Summaries

All 39

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 13
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Macrod2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20481	Chr2:140237341-140237358 (+)	121 bp
Tssr20482	Chr2:140237366-140237385 (+)	147 bp
Tssr20483	Chr2:140431451-140431457 (+)	194,225 bp
Tssr20484	Chr2:140440405-140440416 (+)	203,182 bp
Tssr20485	Chr2:140625609-140625622 (+)	388,387 bp
Tssr20486	Chr2:140807847-140807866 (+)	570,628 bp
Tssr20487	Chr2:141021919-141021926 (+)	784,694 bp
Tssr20488	Chr2:141024818-141024820 (+)	787,590 bp
Tssr20489	Chr2:141453744-141453746 (+)	1,216,516 bp
Tssr20490	Chr2:142059499-142059513 (+)	1,822,277 bp
Tssr20491	Chr2:142059523-142059528 (+)	1,822,297 bp
Tssr20492	Chr2:142059536-142059543 (+)	1,822,311 bp
Tssr20493	Chr2:142061567-142061568 (+)	1,824,339 bp
Tssr20494	Chr2:142215978-142215995 (+)	1,978,758 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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