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Zkscan3 Gene Detail
Summary
  • Symbol
    Zkscan3
  • Name
    zinc finger with KRAB and SCAN domains 3
  • Synonyms
    2810435N07Rik, Skz1, Zfp306, Zfp307
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919989
    NCBI Gene: 72739
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:21571173-21586925 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 7.78 cM, cytoband A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919989
 protein coding gene Chr13:21571173-21586942 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020274
 protein coding gene Chr13:18645213-18663843 (-)
A/J MGP_AJ_G0020230
 protein coding gene Chr13:18241617-18257344 (-)
AKR/J MGP_AKRJ_G0020206
 protein coding gene Chr13:18542312-18561733 (-)
BALB/cJ MGP_BALBcJ_G0020218
 protein coding gene Chr13:18282096-18297832 (-)
C3H/HeJ MGP_C3HHeJ_G0020019
 protein coding gene Chr13:18634874-18651059 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020662
 protein coding gene Chr13:19309587-19328000 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018269
 protein coding gene Chr13:16597995-16613614 (-)
CAST/EiJ MGP_CASTEiJ_G0019556
 protein coding gene Chr13:18445781-18461343 (-)
CBA/J MGP_CBAJ_G0019983
 protein coding gene Chr13:19968190-19990562 (-)
DBA/2J MGP_DBA2J_G0020104
 protein coding gene Chr13:17872294-17890220 (-)
FVB/NJ MGP_FVBNJ_G0020086
 protein coding gene Chr13:17542979-17559253 (-)
LP/J MGP_LPJ_G0020175
 protein coding gene Chr13:18880306-18902518 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020124
 protein coding gene Chr13:20367643-20384825 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020690
 protein coding gene Chr13:18359410-18377166 (-)
PWK/PhJ MGP_PWKPhJ_G0019319
 protein coding gene Chr13:17918201-17934339 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019125
 protein coding gene Chr13:17372197-17389827 (-)
WSB/EiJ MGP_WSBEiJ_G0019613
 protein coding gene Chr13:18442374-18459395 (-)



Homology
more
  • Human Ortholog
    ZKSCAN3, zinc finger with KRAB and SCAN domains 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZKSCAN3, zinc finger with KRAB and SCAN domains 3
  • Synonyms
    dJ874C20.1, dJ874C20.1., ZF47, ZFP306, zfp-47, Zfp47, ZNF306, ZNF309, ZSCAN13, ZSCAN35
  • Links
    NCBI Gene ID: 80317
    neXtProt AC: NX_Q9BRR0
    UniProt: Q9BRR0

  • Chr Location
    6p22.1; chr6:28349878-28369172 (+)  GRCh38
  • Human Ortholog
    ZKSCAN4, zinc finger with KRAB and SCAN domains 4
  • Synonyms
    P1P373C6, ZNF307, ZNF427, ZSCAN36
  • Links
    NCBI Gene ID: 387032
    neXtProt AC: NX_Q969J2
    UniProt: Q969J2

  • Chr Location
    6p22.1; chr6:28241697-28259211 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal weight, size, appearance and autophagy response to starvation and re-feeding. Mice homozygous for a different null allele exhibit increased P. aeruginosa strain K killing in the lungs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    64
  • cDNA Data
    94
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021327 Ensembl Gene Model | MGI Sequence Detail 15753 C57BL/6J ±  kb
transcript ENSMUST00000116434 Ensembl | MGI Sequence Detail 2600 Not Applicable  
polypeptide ENSMUSP00000112135 Ensembl | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 96
    cDNA 95
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2145147, MGI:2145185
References
more
  • Summaries
    All 55
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:335763 Ouyang X, et al., Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload. Physiol Rep. 2023 May;11(9):e15686
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory