Nup37 MGI Mouse Gene Detail - MGI:1919964

Symbol

Nup37
Name

nucleoporin 37
Synonyms

2410003L22Rik, 2810039M17Rik

Feature Type

protein coding gene
IDs

MGI:1919964
NCBI Gene: 69736
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:87982854-88014252 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 43.70 cM, cytoband C2
Mapping Data

2 experiments

SNPs within 2kb

202 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919964	protein coding gene	Chr10:87982838-88014257 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017623	protein coding gene	Chr10:89215011-89247732 (+)
A/J	MGP_AJ_G0017602	protein coding gene	Chr10:86207201-86240167 (+)
AKR/J	MGP_AKRJ_G0017560	protein coding gene	Chr10:88657492-88688730 (+)
BALB/cJ	MGP_BALBcJ_G0017565	protein coding gene	Chr10:86486924-86519257 (+)
C3H/HeJ	MGP_C3HHeJ_G0017388	protein coding gene	Chr10:88637111-88668277 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018022	protein coding gene	Chr10:92211183-92244192 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015704	protein coding gene	Chr10:81968724-82001389 (+)
CAST/EiJ	MGP_CASTEiJ_G0016953	protein coding gene	Chr10:88540011-88571353 (+)
CBA/J	MGP_CBAJ_G0017357	protein coding gene	Chr10:96034869-96067737 (+)
DBA/2J	MGP_DBA2J_G0017463	protein coding gene	Chr10:85325186-85357159 (+)
FVB/NJ	MGP_FVBNJ_G0017455	protein coding gene	Chr10:84552664-84585151 (+)
LP/J	MGP_LPJ_G0017537	protein coding gene	Chr10:89890724-89923429 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017486	protein coding gene	Chr10:97546325-97579866 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018059	protein coding gene	Chr10:88488512-88521713 (+)
PWK/PhJ	MGP_PWKPhJ_G0016734	protein coding gene	Chr10:85333883-85366644 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016522	protein coding gene	Chr10:87221767-87253011 (+)
WSB/EiJ	MGP_WSBEiJ_G0017012	protein coding gene	Chr10:88459646-88495996 (+)

Human Ortholog

NUP37, nucleoporin 37

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUP37, nucleoporin 37
Synonyms

MCPH24, p37
Links

HGNC:29929

NCBI Gene ID: 79023

neXtProt AC: NX_Q8NFH4

UniProt: Q8NFH4
Chr Location

12q23.2; chr12:102073103-102120120 (-) GRCh38

Alliance of Genome Resources

Nup37 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUP37
Gene Tree

Nup37

Diseases

1 with human NUP37 associations

				Human Disease	Mouse Models
				primary autosomal recessive microcephaly IDs primary autosomal recessive microcephaly DOID:0070296 OMIM:PS251200 ORDO:2512

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

10
Targeted

3
Genomic Mutations

1 involving Nup37
Find Mice (IMSR)

11 strains or lines available

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

40
cDNA Data

43
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup37

ZFIN nup37

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Nup37 interacts with 28 markers (Mir17, Mir20b, Mir93, ...) View All

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All Sequences

51
RefSeq

6
UniProt

2
CCDS

CCDS24107.1

Ensembl

ENSMUSG00000035351 (Evidence)
NCBI Gene

69736

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035351	Ensembl Gene Model \| MGI Sequence Detail	31399	C57BL/6J	± kb
transcript	ENSMUST00000052355	Ensembl \| MGI Sequence Detail	1267	Not Applicable
polypeptide	ENSMUSP00000059880	Ensembl \| MGI Sequence Detail	326	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011517 nucleoporin Nup37

(term hierarchy)
InterPro Domains

IPR037626 Nucleoporin Nup37

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 43

cDNA 43

Microarray probesets 3

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MGI:1916986

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

TSS for Nup37:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95142	Chr10:87982857-87982899 (+)	24 bp
Tssr95143	Chr10:87982902-87982915 (+)	55 bp
Tssr95144	Chr10:87982916-87982921 (+)	65 bp
Tssr95145	Chr10:87982923-87982938 (+)	77 bp
Tssr95146	Chr10:87998046-87998047 (+)	15,193 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/19/2023 MGI 6.22