Dnajc6 MGI Mouse Gene Detail - MGI:1919935 - DnaJ heat shock protein family (Hsp40) member C6

Symbol

Dnajc6
Name

DnaJ heat shock protein family (Hsp40) member C6
Synonyms

2810027M23Rik, auxilin, mKIAA0473

Feature Type

protein coding gene
IDs

MGI:1919935
NCBI Gene: 72685
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr4:101353845-101499996 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 46.89 cM
Mapping Data

1 experiment

SNPs within 2kb

1034 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919935	protein coding gene	Chr4:101353828-101499996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028493	protein coding gene	Chr4:101807142-101959945 (+)
A/J	MGP_AJ_G0028456	protein coding gene	Chr4:98245470-98393606 (+)
AKR/J	MGP_AKRJ_G0028403	protein coding gene	Chr4:100621947-100773153 (+)
BALB/cJ	MGP_BALBcJ_G0028474	protein coding gene	Chr4:98463068-98609916 (+)
C3H/HeJ	MGP_C3HHeJ_G0028187	protein coding gene	Chr4:101421257-101573190 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028913	protein coding gene	Chr4:105651171-105808532 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026205	protein coding gene	Chr4:93515986-93662868 (+)
CAST/EiJ	MGP_CASTEiJ_G0027627	protein coding gene	Chr4:99200713-99362362 (+)
CBA/J	MGP_CBAJ_G0028156	protein coding gene	Chr4:108973193-109133469 (+)
DBA/2J	MGP_DBA2J_G0028306	protein coding gene	Chr4:97937832-98088312 (+)
FVB/NJ	MGP_FVBNJ_G0028273	protein coding gene	Chr4:96780019-96927132 (+)
LP/J	MGP_LPJ_G0028406	protein coding gene	Chr4:102111898-102265221 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028301	protein coding gene	Chr4:114519080-114669622 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028951	protein coding gene	Chr4:100874544-101035113 (+)
PWK/PhJ	MGP_PWKPhJ_G0027352	protein coding gene	Chr4:96113989-96264414 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027174	protein coding gene	Chr4:98326213-98479703 (+)
WSB/EiJ	MGP_WSBEiJ_G0027705	protein coding gene	Chr4:101042991-101193987 (+)

Human Ortholog

DNAJC6, DnaJ heat shock protein family (Hsp40) member C6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJC6, DnaJ heat shock protein family (Hsp40) member C6
Synonyms

DJC6, PARK19
Links

HGNC:15469

NCBI Gene ID: 9829

neXtProt AC: NX_O75061

UniProt: O75061
Chr Location

1p31.3; chr1:65264694-65415869 (+) GRCh38.p7

Alliance of Genome Resources

Dnajc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJC6
Gene Tree

Dnajc6

Diseases

2 with human DNAJC6 associations

				Human Disease	Mouse Models
				Parkinson's disease IDs Parkinson's disease DOID:14330 EFO:0002508 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567
				Parkinson's disease 19A IDs Parkinson's disease 19A DOID:0060891 ICD10CM:G20 OMIM:615528 ORDO:391411

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
4 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

7
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Dnajc6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous and heterozygous for a knock-out allele exhibit postnatal lethality and decreased body weight with homozygotes exhibiting decreased synpatic vesicle recycling.

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1020
Tissues

33
cDNA Data

49
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajc6

ZFIN dnajc6

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Dnajc6 interacts with 324 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

68
RefSeq

12
UniProt

3
CCDS

CCDS18395.1, CCDS51237.1, CCDS51238.1

Ensembl

ENSMUSG00000028528 (Evidence)
NCBI Gene

72685

			Length	Strain/Species	Flank
genomic	72685	NCBI Gene Model \| MGI Sequence Detail	146152	C57BL/6J	± kb
transcript	NM_001164583	RefSeq \| MGI Sequence Detail	5493	C57BL/6
polypeptide	Q80TZ3	UniProt \| EBI \| MGI Sequence Detail	938	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030384 putative tyrosine-protein phosphatase auxilin

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR035892 C2 domain superfamily

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR029021 Protein-tyrosine phosphatase-like

IPR014020 Tensin phosphatase, C2 domain

IPR029023 Tensin-type phosphatase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 49

cDNA 49

Microarray probesets 4

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 16
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:281691 Roosen DA, et al., Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse. bioRxiv. 2019;

TSS for Dnajc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37995	Chr4:101353742-101353795 (+)	-76 bp
Tssr37996	Chr4:101353873-101353919 (+)	51 bp
Tssr37997	Chr4:101364674-101364692 (+)	10,838 bp
Tssr37998	Chr4:101364958-101364969 (+)	11,119 bp
Tssr37999	Chr4:101364981-101364997 (+)	11,144 bp
Tssr38000	Chr4:101365052-101365065 (+)	11,214 bp
Tssr38001	Chr4:101365128-101365138 (+)	11,288 bp
Tssr38002	Chr4:101365144-101365229 (+)	11,342 bp
Tssr38003	Chr4:101365296-101365327 (+)	11,467 bp
Tssr38004	Chr4:101407496-101407524 (+)	53,665 bp
Tssr38005	Chr4:101407537-101407571 (+)	53,709 bp
Tssr38006	Chr4:101407574-101407595 (+)	53,740 bp
Tssr38007	Chr4:101407608-101407629 (+)	53,774 bp
Tssr38008	Chr4:101407996-101408021 (+)	54,164 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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