Proser1 Gene Detail

Summary

• Symbol
  Proser1
• Name
  proline and serine rich 1
• Synonyms
  2810046L04Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1919933
  NCBI Gene: 212127
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr3:53371216-53389176 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 25.17 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  60 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919933	protein coding gene	Chr3:53371087-53389176 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027206	protein coding gene	Chr3:52060721-52080192 (+)
A/J	MGP_AJ_G0027166	protein coding gene	Chr3:50488123-50507025 (+)
AKR/J	MGP_AKRJ_G0027135	protein coding gene	Chr3:51510431-51530182 (+)
BALB/cJ	MGP_BALBcJ_G0027178	protein coding gene	Chr3:50353613-50372008 (+)
C3H/HeJ	MGP_C3HHeJ_G0026921	protein coding gene	Chr3:51740649-51759887 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027624	protein coding gene	Chr3:54080750-54098770 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024984	protein coding gene	Chr3:47064419-47082888 (+)
CAST/EiJ	MGP_CASTEiJ_G0026374	protein coding gene	Chr3:51838992-51856966 (+)
CBA/J	MGP_CBAJ_G0026898	protein coding gene	Chr3:55787627-55809030 (+)
DBA/2J	MGP_DBA2J_G0027032	protein coding gene	Chr3:50071792-50090781 (+)
FVB/NJ	MGP_FVBNJ_G0027000	protein coding gene	Chr3:49051048-49069077 (+)
LP/J	MGP_LPJ_G0027144	protein coding gene	Chr3:52787757-52808021 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027018	protein coding gene	Chr3:59904921-59924248 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027683	protein coding gene	Chr3:51422314-51441694 (+)
PWK/PhJ	MGP_PWKPhJ_G0026106	protein coding gene	Chr3:49733201-49752211 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025919	protein coding gene	Chr3:51143758-51219136 (+)
WSB/EiJ	MGP_WSBEiJ_G0026448	protein coding gene	Chr3:51533113-51551187 (+)

Homology

• Human Ortholog
  PROSER1, proline and serine rich 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  PROSER1, proline and serine rich 1
  
• Synonyms
  C13orf23
• Links
  HGNC:20291

  NCBI Gene ID: 80209

  neXtProt AC: NX_Q86XN7

  UniProt: Q86XN7

  
  
• Chr Location
  13q13.3; chr13:39009865-39038115 (-)  GRCh38.p7

---

• Alliance of Genome Resources
  Proser1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: PROSER1
• Gene Tree
  Proser1
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotype references
  

• All Mutations and Alleles
  16
• Gene trapped
  12
• Radiation induced
  2
• Targeted
  2
• Genomic Mutations
  2 involving Proser1
• Incidental Mutations
  APF , CvDC
• Find Mice (IMSR)
  30 strains or lines available

Expression

• Assay Results
  706
• cDNA Data
  52

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase proser1

Interactions

• Proser1 interacts with 243 markers (Mir1b, Mir10a, Mir10b, ...) View All

Sequences &
Gene Models

• All Sequences
  48
• RefSeq
  2
• UniProt
  6
• CCDS
  CCDS17346.1

• Ensembl
  ENSMUSG00000049504 (Evidence)
• NCBI Gene
  212127

Representative Sequences			Length	Strain/Species
genomic	212127	NCBI Gene Model | MGI Sequence Detail	17961	C57BL/6J
transcript	NM_173382	RefSeq | MGI Sequence Detail	4343	C57BL/6
polypeptide	Q5PRE5	UniProt | EBI | MGI Sequence Detail	913	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000030636 proline and serine-rich protein 1
  (term hierarchy)
• InterPro Domains
  IPR028011 Domain of unknown function DUF4476
  IPR042616 Proline and serine-rich protein 1

Molecular
Reagents

• All nucleic 53

  cDNA 53

  
  

  Microarray probesets 4

References

• Summaries
  All 30

  Diseases 1

  Phenotypes 12
• Earliest
  J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
• Latest
  J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Proser1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29113	Chr3:53370995-53371011 (+)	-213 bp
Tssr29114	Chr3:53371087-53371102 (+)	-121 bp
Tssr29115	Chr3:53371115-53371130 (+)	-93 bp
Tssr29116	Chr3:53371200-53371243 (+)	6 bp
Tssr29117	Chr3:53371316-53371327 (+)	106 bp
Tssr29118	Chr3:53382751-53382801 (+)	11,560 bp