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Ints8 Gene Detail
Summary
  • Symbol
    Ints8
  • Name
    integrator complex subunit 8
  • Synonyms
    2810013E07Rik, D130008D20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919906
    NCBI Gene: 72656
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:11199158-11254258 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 5.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2931 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919906
 protein coding gene Chr4:11199158-11254264 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028050
 protein coding gene Chr4:7846758-7902318 (-)
A/J MGP_AJ_G0028007
 protein coding gene Chr4:7734549-7789993 (-)
AKR/J MGP_AKRJ_G0027973
 protein coding gene Chr4:7812741-7868338 (-)
BALB/cJ MGP_BALBcJ_G0028019
 protein coding gene Chr4:7647071-7702306 (-)
C3H/HeJ MGP_C3HHeJ_G0027749
 protein coding gene Chr4:7964290-8021313 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028462
 protein coding gene Chr4:8260615-8319764 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025806
 protein coding gene Chr4:7241500-7295813 (-)
CAST/EiJ MGP_CASTEiJ_G0027203
 protein coding gene Chr4:7789351-7846019 (-)
CBA/J MGP_CBAJ_G0027724
 protein coding gene Chr4:8455126-8519256 (-)
DBA/2J MGP_DBA2J_G0027865
 protein coding gene Chr4:7602122-7657386 (-)
FVB/NJ MGP_FVBNJ_G0027831
 protein coding gene Chr4:7436752-7491999 (-)
LP/J MGP_LPJ_G0027975
 protein coding gene Chr4:7928190-7985785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027864
 protein coding gene Chr4:8662258-8720292 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028521
 protein coding gene Chr4:7812219-7868048 (-)
PWK/PhJ MGP_PWKPhJ_G0026924
 protein coding gene Chr4:7598973-7656826 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026754
 protein coding gene Chr4:7735375-7793291 (-)
WSB/EiJ MGP_WSBEiJ_G0027282
 protein coding gene Chr4:7876543-7932993 (-)



Homology
more
  • Human Ortholog
    INTS8, integrator complex subunit 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS8, integrator complex subunit 8
  • Synonyms
    C8orf52, INT8, NEDCHS
  • Links
    NCBI Gene ID: 55656
    UniProt: Q75QN2

  • Chr Location
    8q22.1; chr8:94813311-94881746 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    4
  • cDNA Data
    14
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040738 Ensembl Gene Model | MGI Sequence Detail 55101 C57BL/6J ±  kb
transcript ENSMUST00000249941 Ensembl | MGI Sequence Detail 3220 Not Applicable  
polypeptide ENSMUSP00000160036 Ensembl | MGI Sequence Detail 1009 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140521, MGI:2443351
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory