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Frmd4a Gene Detail
Summary
  • Symbol
    Frmd4a
  • Name
    FERM domain containing 4A
  • Synonyms
    2700017I06Rik, C230040M21Rik, Gm13190, mKIAA1294
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919850
    NCBI Gene: 209630
  • Alliance
    genome feature page
  • Transcription Start Sites
    46 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:4022528-4618854 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 2.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16687 from dbSNP Build 142
  • Strain Annotations
    38
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919850
 protein coding gene Chr2:4022461-4618854 (+)
129S1/SvImJ ENSMUSG00200031028
 protein coding gene Chr2:1098854-1100467 (+)
129S1/SvImJ ENSMUSG00200030585
 protein coding gene Chr2:1427322-1473760 (+)
129S1/SvImJ ENSMUSGG00200054742
 protein coding gene Chr2:1146367-1391074 (+)
A/J ENSMUSG00195015303
 protein coding gene Chr2:1143524-1145137 (+)
A/J ENSMUSGG00195055205
 protein coding gene Chr2:1262315-1509767 (+)
A/J ENSMUSG00195015130
 protein coding gene Chr2:1546029-1592566 (+)
AKR/J ENSMUSG00220005557
 protein coding gene Chr2:1131234-1132847 (+)
AKR/J ENSMUSG00220005490
 protein coding gene Chr2:1537585-1584117 (+)
AKR/J ENSMUSGG00220054647
 protein coding gene Chr2:1253912-1501328 (+)
BALB/cJ ENSMUSGG00180055336
 protein coding gene Chr2:1355713-1603105 (+)
BALB/cJ ENSMUSG00180028773
 protein coding gene Chr2:1639366-1685904 (+)
BALB/cJ ENSMUSG00180029021
 protein coding gene Chr2:1236934-1238547 (+)
C3H/HeJ ENSMUSG00175015489
 protein coding gene Chr2:1133614-1135227 (+)
C3H/HeJ ENSMUSGG00175054924
 protein coding gene Chr2:1252411-1499781 (+)
C3H/HeJ ENSMUSG00175015378
 protein coding gene Chr2:1536034-1582573 (+)
C57BL/6NJ ENSMUSG00215011548
 protein coding gene Chr2:1257892-1259505 (+)
C57BL/6NJ ENSMUSG00215010845
 protein coding gene Chr2:1660680-1707222 (+)
C57BL/6NJ ENSMUSGG00215055488
 protein coding gene Chr2:1377010-1624423 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023142
 protein coding gene Chr2:863718-1448287 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054582
 protein coding gene Chr2:1292685-1540062 (+)
CBA/J ENSMUSG00210027306
 protein coding gene Chr2:1576323-1622862 (+)
CBA/J ENSMUSG00210027517
 protein coding gene Chr2:1173911-1175524 (+)
DBA/2J ENSMUSG00185012244
 protein coding gene Chr2:1133361-1134974 (+)
DBA/2J ENSMUSGG00185057683
 protein coding gene Chr2:1252154-1499549 (+)
DBA/2J ENSMUSG00185012191
 protein coding gene Chr2:1535807-1582345 (+)
FVB/NJ ENSMUSG00205023671
 protein coding gene Chr2:1523169-1569707 (+)
FVB/NJ ENSMUSGG00205054439
 protein coding gene Chr2:1239869-1486914 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230002330
 protein coding gene Chr2:3475350-3521784 (+)
LP/J ENSMUSGG00230055309
 protein coding gene Chr2:3194639-3439106 (+)
LP/J ENSMUSG00230002378
 protein coding gene Chr2:3081009-3082622 (+)
NOD/ShiLtJ ENSMUSG00190005502
 protein coding gene Chr2:1120841-1122454 (+)
NOD/ShiLtJ ENSMUSG00190005484
 protein coding gene Chr2:1537978-1584516 (+)
NOD/ShiLtJ ENSMUSGG00190054813
 protein coding gene Chr2:1254317-1501719 (+)
NZO/HlLtJ ENSMUSGG00225055625
 protein coding gene Chr2:10928547-11175952 (+)
NZO/HlLtJ ENSMUSG00225001342
 protein coding gene Chr2:10809765-10811378 (+)
NZO/HlLtJ ENSMUSG00225001291
 protein coding gene Chr2:11212202-11258733 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010024193
 protein coding gene Chr2:989682-1580978 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FRMD4A, FERM domain containing 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FRMD4A, FERM domain containing 4A
  • Synonyms
    bA295P9.4, CCAFCA, FRMD4
  • Links
    NCBI Gene ID: 55691
    UniProt: Q9P2Q2

  • Chr Location
    10p13; chr10:13643706-14462142 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    14
  • cDNA Data
    16
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026657 Ensembl Gene Model | MGI Sequence Detail 596327 C57BL/6J ±  kb
    transcript ENSMUST00000091497 Ensembl | MGI Sequence Detail 6208 Not Applicable  
    polypeptide ENSMUSP00000089079 Ensembl | MGI Sequence Detail 1042 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139010, MGI:2443045, MGI:3711984
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory