Tmem87b MGI Mouse Gene Detail - MGI:1919727

Symbol

Tmem87b
Name

transmembrane protein 87B
Synonyms

2610301K12Rik, 2810431I02Rik

Feature Type

protein coding gene
IDs

MGI:1919727
NCBI Gene: 72477
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:128660038-128696181 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.63 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

1891 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919727	protein coding gene	Chr2:128659991-128696181 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026476	protein coding gene	Chr2:132182154-132220156 (+)
A/J	MGP_AJ_G0026440	protein coding gene	Chr2:126824461-126860586 (+)
AKR/J	MGP_AKRJ_G0026415	protein coding gene	Chr2:130419759-130457165 (+)
BALB/cJ	MGP_BALBcJ_G0026452	protein coding gene	Chr2:127085160-127121443 (+)
C3H/HeJ	MGP_C3HHeJ_G0026195	protein coding gene	Chr2:130934067-130972195 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026897	protein coding gene	Chr2:136303745-136347908 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024274	protein coding gene	Chr2:121648761-121686181 (+)
CAST/EiJ	MGP_CASTEiJ_G0025656	protein coding gene	Chr2:131178699-131218485 (+)
CBA/J	MGP_CBAJ_G0026175	protein coding gene	Chr2:141348858-141390301 (+)
DBA/2J	MGP_DBA2J_G0026309	protein coding gene	Chr2:126210692-126246652 (+)
FVB/NJ	MGP_FVBNJ_G0026273	protein coding gene	Chr2:124859304-124895676 (+)
LP/J	MGP_LPJ_G0026414	protein coding gene	Chr2:132404050-132443378 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026293	protein coding gene	Chr2:145281009-145318894 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026952	protein coding gene	Chr2:130464709-130501903 (+)
PWK/PhJ	MGP_PWKPhJ_G0025392	protein coding gene	Chr2:125786514-125822976 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025194	protein coding gene	Chr2:129569925-129607682 (+)
WSB/EiJ	MGP_WSBEiJ_G0025730	protein coding gene	Chr2:131371267-131408781 (+)

Human Ortholog

TMEM87B, transmembrane protein 87B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM87B, transmembrane protein 87B
Links

HGNC:25913

NCBI Gene ID: 84910

UniProt: Q96K49
Chr Location

2q13; chr2:112055269-112119318 (+) GRCh38

MGI Vertebrate Homology

Tmem87b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMEM87B
Gene Tree

Tmem87b

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

6
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Tmem87b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

4
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

3
cDNA Data

108
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem87b

ZFIN tmem87b

less

All Sequences

59
RefSeq

8
UniProt

3
CCDS

CCDS38234.1, CCDS89553.1

Ensembl

ENSMUSG00000014353 (Evidence)
NCBI Gene

72477

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014353	Ensembl Gene Model \| MGI Sequence Detail	36144	C57BL/6J	± kb
transcript	ENSMUST00000110325	Ensembl \| MGI Sequence Detail	4807	Not Applicable
polypeptide	ENSMUSP00000105954	Ensembl \| MGI Sequence Detail	555	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000029812 transmembrane protein 87B

(term hierarchy)
InterPro Domains

IPR009637 Transmembrane protein GPR107/GPR108-like
GlyGen

Q8BKU8 5 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)

less

All nucleic 108

cDNA 108

Microarray probesets 4

less

MGI:1919987, MGI:2139147

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem87b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20081	Chr2:128660024-128660055 (+)	2 bp
Tssr20082	Chr2:128660215-128660271 (+)	205 bp
Tssr20083	Chr2:128661422-128661426 (+)	1,386 bp
Tssr20084	Chr2:128662618-128662638 (+)	2,590 bp
Tssr20085	Chr2:128675637-128675641 (+)	15,601 bp
Tssr20086	Chr2:128687497-128687503 (+)	27,462 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24