Tbcd MGI Mouse Gene Detail - MGI:1919686 - tubulin-specific chaperone d

Symbol

Tbcd
Name

tubulin-specific chaperone d
Synonyms

2310057L06Rik, A030005L14Rik, mKIAA0988

Feature Type

protein coding gene
IDs

MGI:1919686
NCBI Gene: 108903
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:121342817-121507996 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 85.41 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

3366 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919686	protein coding gene	Chr11:121342775-121507996 (+)
129S1/SvImJ	ENSMUSG00200050922	protein coding gene	Chr11:118706689-118870292 (+)
A/J	ENSMUSG00195028246	protein coding gene	Chr11:118382633-118547907 (+)
AKR/J	ENSMUSG00220023390	protein coding gene	Chr11:118532969-118698249 (+)
BALB/cJ	ENSMUSG00180045885	protein coding gene	Chr11:118679105-118844792 (+)
C3H/HeJ	ENSMUSG00175044931	protein coding gene	Chr11:118633032-118798288 (+)
C57BL/6NJ	ENSMUSG00215045713	protein coding gene	Chr11:118203111-118368373 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017566	protein coding gene	Chr11:117347902-117511076 (+)
CAST/EiJ	ENSTCUG00005031817	protein coding gene	Chr11:118041113-118205372 (+)
CBA/J	ENSMUSG00210048166	protein coding gene	Chr11:118347069-118512327 (+)
DBA/2J	ENSMUSG00185022815	protein coding gene	Chr11:118660220-118825476 (+)
FVB/NJ	ENSMUSG00205027619	protein coding gene	Chr11:118505853-118671123 (+)
JF1/MsJ	ENSUMUG00000044387	protein coding gene	Chr11:118945858-119108226 (+)
LP/J	ENSMUSG00230049866	protein coding gene	Chr11:119721334-119886981 (+)
NOD/ShiLtJ	ENSMUSG00190044678	protein coding gene	Chr11:118731446-118896707 (+)
NZO/HlLtJ	ENSMUSG00225026711	protein coding gene	Chr11:121891369-122057025 (+)
PWK/PhJ	ENSLUMG00010019086	protein coding gene	Chr11:118445225-118609318 (+)
SPRET/EiJ	ENSMSPG00010033447	protein coding gene	Chr11:119084588-119248544 (+)
WSB/EiJ	ENSIUOG00005037688	protein coding gene	Chr11:118470393-118633728 (+)

Human Ortholog

TBCD, tubulin folding cofactor D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBCD, tubulin folding cofactor D
Synonyms

PEBAT, SSD-1, tfcD
Links

HGNC:11581

NCBI Gene ID: 6904

UniProt: Q9BTW9
Chr Location

17q25.3; chr17:82751855-82945918 (+) GRCh38

MGI Vertebrate Homology

Tbcd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBCD
Gene Tree

Tbcd

Diseases

1 with human TBCD associations

				Human Disease	Mouse Models
				early onset progressive encephalopathy with brain atrophy and thin corpus callosum IDs early onset progressive encephalopathy with brain atrophy and thin corpus callosum DOID:0070423 OMIM:617193 ORDO:496641

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
1 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

5
Gene trapped

15
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

68 strains or lines available

Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and somite formation.

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All GO Annotations

55
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbcd

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All Sequences

75
RefSeq

10
UniProt

5
CCDS

CCDS25778.1

Ensembl

ENSMUSG00000039230 (Evidence)
NCBI Gene

108903

			Length	Strain/Species	Flank
genomic	108903	NCBI Gene Model \| MGI Sequence Detail	165180	C57BL/6J	± kb
transcript	NM_029878	RefSeq \| MGI Sequence Detail	3870	C57BL/6
polypeptide	Q8BYA0	UniProt \| EBI \| MGI Sequence Detail	1196	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016128 tubulin-specific chaperone D

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR033162 Tubulin-folding cofactor D

IPR058033 Tubulin-folding cofactor D, ARM repeats

IPR022577 Tubulin-folding cofactor D, C-terminal domain

IPR063417 Tubulin-specific chaperone D-like, ARM repeat
GlyGen

Q8BYA0 1 site, 1 O-linked glycan (1 site)

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All nucleic 11

cDNA 11

Microarray probesets 3

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MGI:1924463

Summaries

All 40

Gene Ontology 7

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tbcd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr106405	Chr11:121342780-121342796 (+)	-29 bp
Tssr106406	Chr11:121342799-121342862 (+)	14 bp
Tssr106407	Chr11:121378789-121378830 (+)	35,993 bp
Tssr106408	Chr11:121410246-121410262 (+)	67,437 bp
Tssr106409	Chr11:121435023-121435047 (+)	92,218 bp
Tssr106410	Chr11:121440671-121440682 (+)	97,860 bp
Tssr106411	Chr11:121447045-121447049 (+)	104,230 bp
Tssr106412	Chr11:121450575-121450587 (+)	107,764 bp
Tssr106413	Chr11:121483390-121483398 (+)	140,577 bp
Tssr106414	Chr11:121483419-121483439 (+)	140,612 bp
Tssr106415	Chr11:121492519-121492536 (+)	149,711 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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