Tsnaxip1 Gene Detail

Summary

• Symbol
  Tsnaxip1
• Name
  translin-associated factor X (Tsnax) interacting protein 1
• Synonyms
  1700016K08Rik, TXI1

• Feature Type
  protein coding gene
• IDs
  MGI:1919486
  NCBI Gene: 72236
• Alliance
  genome feature page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr8:106554363-106571312 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 53.04 cM, cytoband D2
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  341 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919486	protein coding gene	Chr8:106554343-106571312 (+)
129S1/SvImJ	ENSMUSG00200013613	protein coding gene	Chr8:100834226-100851173 (+)
A/J	ENSMUSG00195016166	protein coding gene	Chr8:101156705-101173652 (+)
AKR/J	ENSMUSG00220014850	protein coding gene	Chr8:101299338-101316290 (+)
BALB/cJ	ENSMUSG00180021223	protein coding gene	Chr8:101162502-101179452 (+)
C3H/HeJ	ENSMUSG00175024795	protein coding gene	Chr8:101219217-101236166 (+)
C57BL/6NJ	ENSMUSG00215019046	protein coding gene	Chr8:100833563-100850512 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031496	protein coding gene	Chr8:96960515-96978000 (+)
CAST/EiJ	ENSTCUG00005022200	protein coding gene	Chr8:100600848-100617624 (+)
CBA/J	ENSMUSG00210030824	protein coding gene	Chr8:101146934-101163884 (+)
DBA/2J	ENSMUSG00185005558	protein coding gene	Chr8:107255694-107272643 (+)
FVB/NJ	ENSMUSG00205012981	protein coding gene	Chr8:100131250-100148203 (+)
JF1/MsJ	ENSUMUG00000007418	protein coding gene	Chr8:109588880-109605830 (+)
LP/J	ENSMUSG00230029743	protein coding gene	Chr8:110936100-110953049 (+)
NOD/ShiLtJ	ENSMUSG00190027306	protein coding gene	Chr8:101286119-101303064 (+)
NZO/HlLtJ	ENSMUSG00225021143	protein coding gene	Chr8:114286641-114303590 (+)
PWK/PhJ	ENSLUMG00010003961	protein coding gene	Chr8:101075281-101092147 (+)
SPRET/EiJ	ENSMSPG00010035165	protein coding gene	Chr8:103149865-103165322 (+)
WSB/EiJ	ENSIUOG00005030084	protein coding gene	Chr8:101966447-101983690 (+)

Homology

• Human Ortholog
  TSNAXIP1, translin associated factor X interacting protein 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TSNAXIP1, translin associated factor X interacting protein 1
  
• Synonyms
  TXI1
• Links
  HGNC:18586

  NCBI Gene ID: 55815

  UniProt: Q2TAA8

  
  
• Chr Location
  16q22.1; chr16:67806765-67832148 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tsnaxip1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: TSNAXIP1
• Gene Tree
  Tsnaxip1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  4 phenotypes from multigenic genotypes
  3 phenotype references
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  1
• Gene trapped
  1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  31 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Males homozygous for a null allele show reduced male fertility and impaired sperm motility with asymmetric flagellar waveforms.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  4
• GO References
  3

Expression

• Assay Results
  620
• Tissues
  10
• cDNA Data
  10
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  39
• RefSeq
  6
• UniProt
  3
• CCDS
  CCDS22614.1

• Ensembl
  ENSMUSG00000031893 (Evidence)
• NCBI Gene
  72236

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000031893	Ensembl Gene Model | MGI Sequence Detail	16950	C57BL/6J
transcript	ENSMUST00000034365	Ensembl | MGI Sequence Detail	2210	Not Applicable
polypeptide	ENSMUSP00000034365	Ensembl | MGI Sequence Detail	704	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000016733 translin-associated factor X-interacting protein 1
  (term hierarchy)
• InterPro Domains
  IPR032755 Translin-associated factor X-interacting protein 1, N-terminal

Molecular
Reagents

• All nucleic 11

  cDNA 10

  Primer pair 1

  
  

  Microarray probesets 3

References

• Summaries
  All 28

  Developmental Gene Expression 2

  Gene Ontology 3

  Phenotypes 3
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:340908 Kaneda Y, et al., Testis-specific proteins, TSNAXIP1 and 1700010I14RIK, are important for sperm motility and male fertility in mice. Andrology. 2023 Jul;11(5):799-807

TSS for Tsnaxip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79188	Chr8:106554353-106554383 (+)	5 bp
Tssr79189	Chr8:106554385-106554401 (+)	30 bp
Tssr79190	Chr8:106554402-106554405 (+)	41 bp