Tdrp MGI Mouse Gene Detail - MGI:1919398 - testis development related protein

Symbol

Tdrp
Name

testis development related protein
Synonyms

2610019F03Rik

Feature Type

protein coding gene
IDs

MGI:1919398
NCBI Gene: 72148
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:14002008-14025032 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 6.44 cM
Mapping Data

1 experiment

SNPs within 2kb

227 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919398	protein coding gene	Chr8:14002008-14025484 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033392	protein coding gene	Chr8:11324998-11347467 (-)
A/J	MGP_AJ_G0033373	protein coding gene	Chr8:10923879-10949993 (-)
AKR/J	MGP_AKRJ_G0033303	protein coding gene	Chr8:11198036-11220384 (-)
BALB/cJ	MGP_BALBcJ_G0033373	protein coding gene	Chr8:11029739-11052734 (-)
C3H/HeJ	MGP_C3HHeJ_G0033086	protein coding gene	Chr8:11431985-11458098 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033885	protein coding gene	Chr8:11701852-11724230 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030852	protein coding gene	Chr8:10358833-10380877 (-)
CAST/EiJ	MGP_CASTEiJ_G0032408	protein coding gene	Chr8:11215291-11241982 (-)
CBA/J	MGP_CBAJ_G0033059	protein coding gene	Chr8:12192045-12218218 (-)
DBA/2J	MGP_DBA2J_G0033213	protein coding gene	Chr8:10862860-10885713 (-)
FVB/NJ	MGP_FVBNJ_G0033161	protein coding gene	Chr8:10876235-10901784 (-)
LP/J	MGP_LPJ_G0033306	protein coding gene	Chr8:11294823-11326284 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033198	protein coding gene	Chr8:12438673-12461026 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033902	protein coding gene	Chr8:11295931-11319100 (-)
PWK/PhJ	MGP_PWKPhJ_G0032121	protein coding gene	Chr8:10917374-10941999 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031962	protein coding gene	Chr8:11155911-11177619 (-)
WSB/EiJ	MGP_WSBEiJ_G0032524	protein coding gene	Chr8:11317944-11342724 (-)

Human Ortholog

TDRP, testis development related protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDRP, testis development related protein
Synonyms

C8orf42, Inm01, TDRP1, TDRP2
Links

HGNC:26951

NCBI Gene ID: 157695

neXtProt AC: NX_Q86YL5

UniProt: Q86YL5
Chr Location

8p23.3; chr8:489790-545781 (-) GRCh38.p7

Alliance of Genome Resources

Tdrp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TDRP
Gene Tree

Tdrp

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

1
Targeted

4
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Null males exhibit impaired sperm motility but normal fertility.

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All GO Annotations

8
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

98
cDNA Data

73
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdrp

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Tdrp interacts with 196 markers (Mir15a, Mir20a, Mir23a, ...) View All

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All Sequences

63
RefSeq

16
UniProt

4
CCDS

CCDS22119.1

Ensembl

ENSMUSG00000050052 (Evidence)
NCBI Gene

72148

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050052	Ensembl Gene Model \| MGI Sequence Detail	23025	C57BL/6J	± kb
transcript	ENSMUST00000062613	Ensembl \| MGI Sequence Detail	2463	Not Applicable
polypeptide	ENSMUSP00000058371	Ensembl \| MGI Sequence Detail	182	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000059907 testis development-related protein

(term hierarchy)
InterPro Domains

IPR031399 Testis development-related protein

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All nucleic 73

cDNA 73

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:290472 Piras G, et al., Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Brain Behav Immun. 2020 Feb 29;

TSS for Tdrp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80472	Chr8:14025045-14025074 (-)	-28 bp
Tssr80471	Chr8:14024953-14024969 (-)	71 bp
Tssr80470	Chr8:14024923-14024946 (-)	97 bp
Tssr80469	Chr8:14024715-14024737 (-)	306 bp
Tssr80468	Chr8:14024676-14024698 (-)	345 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/24/2023 MGI 6.22